期刊文献+

NF-κB在胃癌中的检测及意义

下载PDF
导出
摘要 目的探讨NF-κB胃癌中的表达量及与临床病理参数的关系。方法选取2013年7月2015年7月广西医科大学附属肿瘤医院收治的78例胃癌组织作为观察组,另选取同期26例正常组织作为对照组,观察两组患者NF-κB蛋白表达情况。结果胃癌组患者NF-κB蛋白阳性率高于正常组(P<0.05);NF-κB的表达率与临床分期、分化程度、有无淋巴结转移有关(P<0.05);结论 NF-κB蛋白在胃癌中的表达率高,对于判断肿瘤的恶性程度及预后重要的临床意义。
作者 李吉玲
机构地区 广西医科大学
出处 《生物技术世界》 2016年第2期115-115,117,共2页 Biotech World
  • 相关文献

参考文献9

  • 1Hayakawa Y,Hirata Y,Nakagawa H,et al.Apoptosis signalregulatingkinase 1 and cyclinD1 compose a Positive feedbackloop contributing to tumor growth in gastric cancer[J]. ProcNatl Acad Sci USA,2011,108(2): 780-785.
  • 2Zhao XD,Lu YY,Guo H, et,al. MicroRNA-7/NF-κB signaling regulatoryfeedback circuit regulates gastric carcinogenesis[J]. JCell Biol.2015;210(4):613-27.
  • 3Huan Y1,Wu D2,Zhou D, et al. DBC1 promotes anoikis resistanceof gastric cancer cells by regulating-NF- κ B activity[J]. Oncol Rep.2015 Aug;34(2):843-9.
  • 4Camp ER,Li J,Minnich DJ, et al,Inducible nuclear factorkappaBactivation contributes to chemotherapy resistance ingastric cancer.JAM Coll Surg,2004.199(2):249-258.
  • 5Chao X,Zao J,Xiao-Yi G,et al,Blocking of PI3K/ALK inducesapoptosis-by its effect on NF-kappaB activity in gastric carcinomacell line SGC7901.Biomed Pharmacother. 2010. 64(9):600-604.
  • 6Zhang ZX,Liu ZQ,Jiang B,et al.BRAF activated non-coding RNA(BANCR) promoting gastriccancer cells proliferation via regulationof NF- κ B1[J].Biochem Biophys Res Commun.2015;465(2):225-31.
  • 7Huan Y,Wu D,Zhou D,et al. DBC1 promotes anoikis resistanceof gastric cancer cells by regulating-NF- κ B activity[J].OncolRep.2015;34(2):843-9.
  • 8Rengarajan T1,Nandakumar N,-Rajendran P,et al.D-pinitolmitigates tumor growth by modulating interleukins and hormonesand induces apoptosis in rat breast carcinogenesis throughinhibition of NF- κ B[J]. J Physiol Biochem.-2015 Jun;71(2):191-204.
  • 9Liu JP,2,Liu D,Gu JF ,et al. Shikonin inhibits the cell viability,adhesion, invasion and migration of the human gastric cancercell line MGC-803 via the Toll-like receptor 2/nuclear factorkappaB pathway[J].J Pharm Pharmacol.2015;67(8):1143-55.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部