艾迪联合FOLFOX4方案治疗Ⅲ期结肠癌患者术后效果观察

Therapeutic effect of AIDi injection plus FOLFOX4 for stage Ⅲ colon cancer after surgery

目的探讨Ⅲ期结肠癌术后患者应用艾迪注射液联合FOLFOX4方案（奥沙利铂＋亚叶酸钙＋5-氟尿嘧啶）化疗的效果和安全性。方法94例Ⅲ期结肠癌术后患者随机分为观察组46例和对照组48例，对照组给予FOLFOX4方案化疗，21d为1个周期；观察组在对照组治疗基础上静脉滴注艾迪注射液50mL／次，1次／d，第1～5天。完成3个周期化疗后评定2组治疗效果，并记录不良反应发生情况。结果2组均完成3个周期化疗，完全缓解率均为100％；观察组白细胞减少（26．09％）、恶心（38．40％）、呕吐发生率（20．29％）均低于对照组（37．50％、69．44％、45．83％）（P〈0．05）。结论Ⅲ期结肠癌根治术后采用FOLFOX4方案化疗安全有效，联合艾迪注射液可减轻化疗相关不良反应。

Objective To explore the clinical efficacy of AIDi injection plus FOLFOX4 （oxaliplatin＋calcium folinate＋ 5- fluorouraeil） on stage III colon cancer after surgery and its safety. Methods Ninety-four patients with stage III colon cancer were randomly divided into observation group （n= 46） and control group （n = 48）. Control group received FOLFOX4 regimen chemotherapy, for 21 days as one cycle, besides which observation group received AIDi injection 50 mLper time, once a day, by day 1 to 5. The effect was evaluated in two groups after three cycles of chemotherapy, and the adverse reactions were recorded. Results Both two groups completed three cycles of chemotherapy. The complete response rates were 100% in two groups. The incidences of leukopenia, nausea and vomiting were 26.09%, 38.40% and 20.29 % in observation group, significantly lower than those in control group （37.50%, 69.44%, 45.83%） （P〈0.05）. Conclusion After radical resection of stage III colon cancer, chemotherapy with FOLFOX4 regimen is safe and effective, and AIDi injection can reduce the adverse reactions of chemotherapy.