南宁地区孕妇与新生儿TORCH检测结果分析

Analysis on TORCH infection in pregnant women and newborn in Nanning area

目的了解南宁地区孕妇、胎儿与新生儿TORCH感染情况及与不良妊娠和新生儿疾病的关系。方法对2008年1月—2013年12月在广西壮族自治区妇幼保健院就诊的39 281例孕妇、18 757例新生儿外周血和4 833例孕妇产前脐血采用酶联免疫吸附方法检测血清TORCH抗体并收集孕妇和新生儿临床诊断信息,分析不良妊娠组、正常妊娠组脐血及各种新生儿疾病中TORCH-Ig M阳性率。结果 39 281例孕妇、4 833例产前脐血和18757例新生儿TORCH-Ig M总阳性率分别为2.86%、0.89%和1.60%,其中均以CMV-Ig M阳性率最高,分别为0.88%、0.34%和1.31%。不良妊娠组和正常妊娠组脐血TORCH-Ig M总阳性率分别为1.44%和0.45%,2组比较差异有统计学意义(P<0.05);新生儿肝炎综合征、病理性黄疸、败血症和肺炎患儿中TORCH-Ig M阳性率较高,依次为18.75%、2.74%、1.93%和1.64%。结论 CMV是南宁地区孕妇与新生儿感染的主要TORCH病原体,且与新生儿肝炎综合征、病理性黄疸等疾病呈正相关,有必要进行TORCH筛查。

Objective To investigate the status of TORCH infection in pregnant women and newborn and its relationship with abnormal pregnancy and neonatal common diseases in Nanning area. Methods TORCH antibody was detected by u- sing enzyme linked immunosorbent assay method in the serum form 39 281 pregnant women,4 833 cord blood and 18 757 newborn from January 2008 to December 2013. The clinical diagnostic information was coUected and analyzed. The posi- tive of TORCH in abnormal pregnancy group, normal pregnancy group and infants with different diseases were compared. Results The positive rate of TORCH-IgM was 2.86% ,0.89% and 1.60% in 39 281 pregnant women,4 833 cord blood and 18 757 newborns, respectively. And the rate of CMV-IgM was higher than other pathogen in those three groups （0.88% ,0.34% and 1.31% ,respectively）. The positive rate of TORCH-IgM in normal group and abnormal group were 1.44% and 0.45% ,respectively（P 〈 0.05 ）, and was 18.70% ,2.74%, 1.93% and 1.64% in newborn with hepatitis syndrome, pathological jaundice, septicemia and pneumonia, respectively. Conclusion CMV was the main pathogen of in- fection in pregnant women and newborn, and were associated with hepatitis syndrome and pathological jaundice. It is nec- essary to take the screening for TORCH in this area.