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硫酸羟基氯喹治疗盘状红斑狼疮临床疗效分析 被引量:3

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摘要 目的通过评估硫酸羟基氯喹(hydroxychloroquine sulfate,HCQ)对盘状红斑狼疮(discoid lupus erythematosus,DLE)治疗效果,进一步提高DLE临床治疗水平。方法选取杭州萧山区皮肤医院门诊初诊,肝肾功能、血常规、眼底检查结果正常,无严重全身系统疾病及精神异常,且依据临床表现及皮肤病理学检查等确诊为盘状红斑狼疮的患者100例,随机分成2组,HCQ治疗组50例,使用HCQ治疗,用量400 mg/d(200 mg/次,2次/d)治疗4周,后减量为200 mg/d(100 mg/次,2次/d);磷酸氯喹(Chloroquine Phosphate,CQ)治疗组50例,使用CQ治疗,用量500 mg/d(250 mg/次,2次/d)治疗4周,后减量为250 mg/d(125 mg/次,2次/d)。连续治疗16周,应用SPSS18.0统计软件对数据进行统计分析,对2组患者总体有效率进行χ2检验,评估2组治疗效果。结果治疗16周后,HCQ治疗组总体有效率(92.0%)高于CQ治疗组(76.0%),差异有统计学意义(χ2=4.762,df=1,P=0.029);HCQ治疗组副作用发生率为8.0%(4/50),CQ治疗组副作用发生率为20.0%(8/50)。结论应用硫酸羟基氯喹治疗盘状红斑狼疮可显著改善患者临床症状和体征,副反应小,相对安全且治疗效果更佳,因此建议临床广泛应用。
作者 沈东
出处 《中华全科医学》 2016年第1期161-162,共2页 Chinese Journal of General Practice
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参考文献15

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二级参考文献22

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