颈舒十四味治疗神经根型颈椎病(气滞血瘀证)的临床疗效观察

Clinical Observation of Jingshu Shisiwei on Treatment of Cervical Spondylosis Radiculopathy(Qi Stagnation and Blood Stasis Syndrome)

目的观察颈舒十四味在治疗气滞血瘀型神经根型颈椎病的临床疗效。方法将符合该型病例的患者随机分为两组,治疗组(A组)采用颈舒十四味口服处理,对照组(B组)采用根痛平颗粒口服处理,疗程4周。观察指标为比较治疗两组患者疼痛症状VAS评分,各临床症状、体征情况评分及临床症状体征总积分,常规安全性指标。结果(1)颈舒十四味的临床有效率为93.3%、根痛平颗粒的临床有效率为89.7%,治疗4周后,颈舒十四味与根痛平颗粒的疗效相等,两组在疗效方面比较,差异无统计学意义(P>0.05)。(2)两组治疗前后主次症状、体征总积分的比较,差异具有统计学意义(P<0.05),颈舒十四味在改善疼痛方面基本与根痛平颗粒基本相等(P>0.05),但降低临床症状及体征总积分方面优于根痛平颗粒(P<0.05)。(3)颈舒十四味未见任何不良事件,安全性高。结论颈舒十四味在治疗气滞血瘀型神经根型颈椎病方面临床疗效确切,安全性高,值得临床推广应用及进一步深化研究。

Objective To observe the clinical effect of Jingshu Shisiwei on nerve root type cervical spondylosis with qi stagnation and blood stasis syndrome. Methods The patients were randomly divided into two groups. The treatment group （group A） was treated orally with Jingshu Shisiwei, and the control group （group B） was treated with the oral administration of Gentongping Granule. The treatment course was 4 weeks. To observe and compare the therapeutic VAS pain score, the clinical symptoms and signs of improvement, the improvement of clinical symptoms and signs of the total score, and routine safety index. Results （1） The clinical effective rate of Jingshu Shisiwei was 93.33% and Gentongping Granule was 89.66%, after treatment for 4 weeks, the efficacy of Jingshu Shisiwei and Gentongping Granule were similar, the difference was not statistically significant （P〉0.05）. （2） The scores of primary and secondary symptoms and signs in two groups before and after treatment were statistically significant （P〈0.05）, and Jingshushisiwei in improving pain was basically same with Gentongping Granules （P〉0.05）, but in improving clinical symptoms and signs was better than Gentongping Granules （P〈0.05）. （3） Jingshu Shisiwei, with high security, did not show any adverse events. Conclusion The clinical efficacy of Jingshushisiwei in treating cervical spondylosis radiculopathy of Qi stagnation and blood stasis type is accurate, and with high safety, which is worthy of clinical application and further research.