血Cys-C、β_2-MG和尿m-Alb联合检测在糖尿病肾病早期诊断中的临床价值

Clinical value of joint detection of Cys-C and β_2-MG in blood and m-Alb in urine in early diagnosis of diabetic nephropathy

目的 探讨血Cys-C、β2-MG和尿m-Alb联合检测在糖尿病肾病早期诊断中的临床价值。方法 选择2012年3月~2014年5月在我院接受治疗的58例糖尿病肾病患者作为研究对象,设为研究组,选取同期在本院体检正常的58例健康者作为对照组。观察两组患者的Cys-C、β2-MG和尿m-Alb含量并比较单一检测与联合检测阳性率、敏感度、特异度。结果 研究组患者的尿血Cys-C、β2-MG和尿m-Alb含量均显著高于对照组,两组比较,差异均有统计学意义（P〈0.05）;研究组患者的Cys-C检测阳性率为72.4%,β2-MG检测阳性率为56.9%,尿mAlb检测阳性率为62.1%,三项联合检测的阳性率高达89.7%,三项联合检测的阳性率及灵敏度均显著高于任何单一检测,差异均有统计学意义（P〈0.05）;单一检测与联合检测的特异度均基本相符,差异均无统计学意义（P〉0.05）。结论 血Cys-C、β2-MG和尿m-Alb均可以作为糖尿病肾病早期诊断的重要指标,三者联合检测的诊断价值较高,适合临床推广应用。

Objective To explore the clinical value of joint detection of Cys-C and β2-MG in blood and m-Alb in urine in early diagnosis of diabetic nephropathy. Methods From March 2012 to May 2014,58 patients with diabetic nephropathy admitted into our hospital were selected as research object and set as research group.Another group of 58 healthy people after physical examination in our hospital was selected as control group at the same period.The content of Cys-C,β2-MG,and m-Alb in the two groups was observed respectively.The positive rate,sensitivity,and specificity be- tween single detection and joint detection was compared respectively. Results The content of Cys-C and β2-MG in blood and m-Alb in urine in research group was obviously higher than that of control group,and there was a statistical difference between two groups （P〈0.05）.The positive detection rate of Cys-C,β2-MG in blood and m-Alb in urine was 72.4%,56.9% and 62.1% respectively in patients of research group.The positive rate of joint detection of these three indicators reached 89.7%.The positive rate and sensitivity of joint detection was obviously higher than that of any single detection,and there was a statistical difference （P〈0.05）.The specificity between single detection and joint detection was basically in coincidence,and there was no statistical difference （P〉0.05）. Conclusion Cys-C,β2-MG in blood,and m- Alb in urine can be considered as important indicators in early diagnosis of diabetic nephropathy.Joint detection of these three indicators has a higher clinical value,which is applicable for application and promotion in clinic.