O型孕妇产前IgG抗-A(B)抗体效价变化分析

Analysis of IgG anti-A(B) antibody titers in type O pregnant women

目的：探讨O型孕妇产前Ig G抗-A（B）抗体效价的变化及其拐点的出现时间。方法：使用经典抗球蛋白试验检测2 777名O型孕妇血清中Ig G抗-A（B）抗体效价,并按妊娠次数、孕周进行结果分析。结果：随着妊娠次数的增加,血清中Ig G抗-A（B）抗体水平也不断增高,首次妊娠与2次及以上妊娠孕妇血清Ig G抗-A（B）抗体效价相比均存在显著性差异（P〈0.01）;随着孕周的增加,血清中Ig G抗-A（B）抗体水平在16~19周时缓慢增高,在妊娠20周时出现一个明显增高的拐点,而后继续增高并在孕24~28周时达到峰值,随后不再增长。结论：O型孕妇在妊娠20周时应进行Ig G抗-A（B）抗体效价检测,具有多次妊娠史的O型孕妇,体内可能存在高效价的Ig G抗-A（B）抗体,应及时进行抗体检测。

Objective： To investigate the changes and turning point of IgG anti-A （B） antibody titers in type O pregnant women. Methods： IgG anti-A （B） antibody titers of 2 777 type O pregnant women were tested by the classic antiglobulin test and the results were analyzed according to the number of pregnancy and gestational weeks. Results： With the increase of the number of pregnancy, serum IgG anti -A （B） antibody levels were also increased, and significant difference was found in IgG anti -A （B） antibody titers between the first pregnancy and the two or multiple pregnant women （P〈0.01）. With the increase of gestational weeks, serum IgG anti -A （B） antibody level was first increased slowly in 16-19 weeks of pregnancy, with a turning point of marked increase at 20 weeks of pregnancy, after which continued to increase to peak at 24-28 weeks of pregnancy, without any further growth. Conclusion： The type O pregnant women should undergo IgG anti-A （B） antibody titers detection at 20 weeks of pregnancy. The group O pregnant women with multiple pregnancy history should carry out IgG anti -A （B） antibody test in time, because high titer antibodies may exist in their sera.