摘要
目的:探讨O型孕妇产前Ig G抗-A(B)抗体效价的变化及其拐点的出现时间。方法:使用经典抗球蛋白试验检测2 777名O型孕妇血清中Ig G抗-A(B)抗体效价,并按妊娠次数、孕周进行结果分析。结果:随着妊娠次数的增加,血清中Ig G抗-A(B)抗体水平也不断增高,首次妊娠与2次及以上妊娠孕妇血清Ig G抗-A(B)抗体效价相比均存在显著性差异(P〈0.01);随着孕周的增加,血清中Ig G抗-A(B)抗体水平在16~19周时缓慢增高,在妊娠20周时出现一个明显增高的拐点,而后继续增高并在孕24~28周时达到峰值,随后不再增长。结论:O型孕妇在妊娠20周时应进行Ig G抗-A(B)抗体效价检测,具有多次妊娠史的O型孕妇,体内可能存在高效价的Ig G抗-A(B)抗体,应及时进行抗体检测。
Objective: To investigate the changes and turning point of IgG anti-A (B) antibody titers in type O pregnant women. Methods: IgG anti-A (B) antibody titers of 2 777 type O pregnant women were tested by the classic antiglobulin test and the results were analyzed according to the number of pregnancy and gestational weeks. Results: With the increase of the number of pregnancy, serum IgG anti -A (B) antibody levels were also increased, and significant difference was found in IgG anti -A (B) antibody titers between the first pregnancy and the two or multiple pregnant women (P〈0.01). With the increase of gestational weeks, serum IgG anti -A (B) antibody level was first increased slowly in 16-19 weeks of pregnancy, with a turning point of marked increase at 20 weeks of pregnancy, after which continued to increase to peak at 24-28 weeks of pregnancy, without any further growth. Conclusion: The type O pregnant women should undergo IgG anti-A (B) antibody titers detection at 20 weeks of pregnancy. The group O pregnant women with multiple pregnancy history should carry out IgG anti -A (B) antibody test in time, because high titer antibodies may exist in their sera.
出处
《天津医科大学学报》
2016年第1期31-33,共3页
Journal of Tianjin Medical University
关键词
IgG抗-A(B)抗体
新生儿溶血病
拐点
IgG anti-A (B) antibody
haemolytic disease of the newborn
turning point