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肺部苦味受体在哮喘治疗中的研究进展 被引量:1

Research progress of bitter taste receptors in asthmatic therapy
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摘要 研究发现在人类气道平滑肌上存在苦味受体(bitter taste receptors,TAS2Rs),可感知苦味物质,引起局部Ca2+增加,却使肺部支气管高效扩张,从而有效缓解哮喘、慢性阻塞性肺疾病(chronic obstructive pulmonary diseases,COPD)等患者的气道痉挛,降低气道阻力。临床上对于哮喘的治疗仍面临很大难题,肺部TAS2R或许成为一种新的治疗靶点。但其引起气道舒张的确切机制尚不清楚,文中对TAS2R的结构、信号转导及刺激肺部TAS2R引起气道扩张的分子机制进行综述。 Bitter taste receptors have recently been identified on human's airway smooth muscle( ASM), which can perceive bitter substances and evoke increased intracellular calcium ( [ Ca2 + ] i) in airway smooth muscle. They can cause lung bronchial efficient ex- pansion, and thus effectively alleviate airway spasm and airway resistance in asthma, chronic obstructive pulmonary disease. Clinically, the treatment of asthma remains chalXengeabXe, lung TAS2R may be a new treatment target. However, its mechanism is unclear, this paper describes the structure of bitter taste receptors, signal transduction and mechanisms of airway dilatation when bitter taste receptors were activated.
作者 闫珊 高福生
出处 《医学研究生学报》 CAS 北大核心 2016年第1期109-112,共4页 Journal of Medical Postgraduates
关键词 苦味受体 哮喘 钙离子 气道平滑肌 气道舒张 Bitter taste receptors Asthma Calcium ion Airway smooth muscle Bronchodilation
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