心理干预对癌症放疗患者焦虑抑郁情绪应对方式及免疫功能的影响

Impacts of psychological intervention on anxiety-depressive e- motions, coping styles and immune functions of cancer pa- tients undergoing radiotherapy

目的探讨心理干预对癌症放疗患者焦虑抑郁情绪、应对方式及免疫功能的影响。方法将60例合并焦虑抑郁障碍的放疗癌症患者按照随机数字表法分为两组，每组30例，均予以常规放疗及健康教育，干预组在此基础上联合综合心理干预，观察2个月。干预前后应用艾森克人格问卷、应对方式问卷、焦虑自评量表、抑郁自评量表进行测评分析，并测定免疫功能。结果两组艾森克人格问卷的神经质维度分均显著高于常模（P〈0．01），两组间比较差异无显著性（P〉0．05）。干预后干预组焦虑自评量表、抑郁自评量表总分较干预前显著降低（P〈0．01），且显著低于对照组（P〈0．01）；积极应对方式评分较干预前显著升高，且显著高于对照组（P〈0．01）；消极应对方式评分较干预前显著下降，且显著低于对照组（P〈0．01）；各项免疫指标改善显著优于对照组（P〈O．01）。结论癌症患者具有较高的神经质特质，心理干预能显著改善癌症放疗患者的焦虑抑郁情绪，促使患者更多的采用积极应对方式，显著提高患者细胞免疫功能。

Objective To explore the impact of psychological intervention on anxiety-depressive emotions, coping styles and immune functions of cancer patients undergoing radiotherapy. Methods Sixty cancer pa- tients with anxious-depressive disorder were assigned to two groups of 30 ones each according to random number table, both groups received routine radiotherapy and health education, and on this basis interven- tion group was plus comprehensive pyshological intervention for 2 months. Assessments were conducted with the Eysenck Personality Questionnaire （EPQ）, Coping Style Questionnaire （CSQ）, Self-rating Anxi- ety Scale （SAS）, and Self-rating Depression Scale （SDS） before and after intervention, and immune func- tions determined. Results N scores of the EPQ in both groups were significantly higher compared with norm （P〈0.05） and those had no significant group differences （P〉0.05）. After intervention the SAS and SDS total score lowered more significantly compared with pre-intervention in intervention group （P〈 0.01） and were significantly lower than in control group （P〈0.01） ; positive coping score heightened more significantly compared with pre-intervention in intervention group （P〈0.01） and was significantly higher than in control group （P〈0.01） ; negative coping score lowered more significantly compared with pre-in- tervention in intervention group （P〈0.01） and was significantly lower than in control group （P〈0.01）. Intervention outstripped control group in the improvements of all indexes of immune functions （P〈0.01）. Conclusion Cancer patients have higher neuroticism trait, psychological intervention could notably improve anxiety-depressive emotions of cancer patients undergoing radiotherapy, promote patients to adopt more positive coping styles, and boost patients~ immune functions notably.