宫颈癌相关性多原发恶性肿瘤58例临床分析

Multiple primary malignancies associated with cervical cancer: A retrospective analysis of 58 cases

目的探讨宫颈癌相关性多原发恶性肿瘤的临床特点。方法研究分析2008年1月-2014年1月解放军总医院和广西医科大学附属肿瘤医院收治的58例宫颈癌相关性多原发恶性肿瘤患者的临床资料。结果宫颈癌相关性多原发癌的发生率为1.4%;宫颈癌为首发癌和次发癌的患者平均发病年龄分别为51.8岁、55.2岁;平均间隔时间40.19（0~125）个月;子宫颈癌-乳腺癌、宫颈癌-肺癌为最常见组合形式;1年、2年、3年累积生存率分别为82.76%、75.86%和70.69%。结论宫颈癌相关性多原发癌以宫颈癌-乳腺癌、宫颈癌-肺癌最为多见;宫颈癌相关性多原发癌患者肿瘤分期相对较早,预后相对较好。

Objective To analyze the characteristics of multiple primary malignant neoplasms（MPMN） associated with cervical cancer. Methods Clinical data about 58 cases who were diagnosed with MPMN associated with cervical cancer and admitted to Chinese PLA General Hospital and Tumor Hospital of Guangxi Medical University form January 2008 to January 2014 were reviewed retrospectively. Results The rate of cervical cancer accompanied with other primary carcinoma was 1.4 %. The mean age of these patients diagnosed with cancer for the first and second time was 51.8 and 55.2 years old, respectively, with the interval time of 40.19 months（ranged from 0 month to 125 months）. In our study, cervical cancer-breast cancer and cervical cancer-lung cancer were the most common types of tumors. The 1-, 2- and 3-year overall survival rates were 82.76%, 75.86%, 70.69%, respectively. Conclusion Cervical cancer-breast cancer and cervical cancer-lung cancer are the most common type of tumors in these patients diagnosed with MPMN associated with cervical cancer. Furthermore, the prognosis of the early stage of tumors is favorable.