摘要
目的探讨急性化学物中毒所致酸碱平衡紊乱对临床预后的影响。方法回顾性分析1990—2009年近20年间急性化学物中毒105例,分析酸碱平衡紊乱指标中pH值、PaO_2、PaCO_2、多重酸碱平衡紊乱与预后指标如死亡、器官损害及APACHE II评分的关系。结果各指标异常时出现死亡病例。不同pH值组、PaO_2组、酸碱组的器官损害程度、APACHEⅡ评分差异有统计学意义(P<0.05),异常组的器官损害严重程度、APACHEⅡ评分均升高。较重的二氧化碳潴留(PaCO_2>6.0 kPa)可导致多器官损害。结论急性化学物中毒致严重pH值异常、低氧血症、多重酸碱平衡紊乱均影响患者预后,导致不良后果,但在一定程度上能依此判断中毒预后,为临床早期救治提供证据。
Objective To obserye the relationship between prognosis of acute chemical poisoning and acid-base balance disorder among victims. Methods Totally 105 cases of acute chemical poisoning during 1990-2009 were studied retrospectively . The relationship between some indexes such as pH value,paO2,PaCO2,multiple acid-base balance disorders and prognosis such as death ,organ damage and APACHE 11 score was evaluated. Results All dead cases showed the abnormality of pH value,PaO2, or multiple acid-base balance. The cases with abnormality of these indexes had more serious multiple organs damage and their APACHE II score showed significant increment. The cases with severer carbon dioxide retention （PaCO2 〉 6.0 kPa）had more serious multiple organs damage .Conclusion Acute chemical poisoning may cause abnormality of pH, hypoxemia and multiple acid-base balance disorders,which results in severe consequences by affecting prognosis. However,it could provide reference for the early treatment.
出处
《职业卫生与应急救援》
2015年第6期405-407,447,共4页
Occupational Health and Emergency Rescue
