溶液喷射纺凝胶纳米纤维敷料的结构与性能研究

Solution Blowing of Hydrogel Nanofibers for Wound Dressing

论文采用溶液喷射纺丝技术纺制了CS/PLA/PEG纳米纤维,该纤维表面光滑、呈现三维卷曲形态,平均直径为341~376nm。对其进行戊二醛（GA）水蒸汽交联,增强了其在水中的稳定性,并具有快速的溶胀吸湿性、高的保水性和良好透气性,应用于创伤敷料有利于吸收多余的伤口渗出液,保持伤口湿润的愈合环境和空气交换。同时大肠杆菌实验显示了该纤维膜具有良好的抑菌性能。该敷料兼具纳米纤维和水凝胶的特性,是一种理想的生物医用敷料。

In this study,a kind of hydrogel nanofiber was successfully fabricated via solution blowing of chitosan（ CS） and polylactic acid（ PLA） solutions mixed with various contents of polyethylene glycol（ PEG） to offer hydration. The fibers were average 341 ~ 376 nm in diameter with smooth surface and distributed randomly forming three- dimension mats.Glutaraldehyde vapor（ GA） was then applied to impart stability,and the hydrogel nanofibers showed quick absorption behavior,high equilibrate water absorption and good air permeability which could help the mats absorbing excess exudates,creating a moist wound healing environment and oxygen exchanging in wound healing. The mats also exhibited good antibacterial activities against E. coil. The combination advantages of nanofibers mats and hydrogel will help it find promising application in wound healing.