摘要
目的:检测Oct4蛋白在肝细胞癌组织中的表达,并探讨其与临床病理因素的相关性。方法:收集60例病人手术切除的肝细胞癌组织及对应的癌旁组织标本,应用免疫组织化学方法检测Oct4蛋白的表达。结果:肝细胞癌组织Oct4蛋白阳性表达率显著高于癌旁组织(81.67%vs.15.0%)(P<0.05);肝细胞癌组织中Oct4蛋白的表达与肿瘤大小、血管侵犯及TNM分期有关(P<0.05)。结论:Oct4蛋白在肝细胞癌的发生发展中发挥重要作用,可作为判断预后有价值的分子标记物。
Objective：To study the expression of Oct4 protein in hepatocellular carcinoma tissues,and discuss the correlation with clinical pathologic factors.Methods：Collected 60 cases of patients with surgical resection of hepatocellular carcinoma tissues and the corresponding tissues adjacent to carcinoma as specimens,immnohisochemical technique was used to detect the expression of Oct4 protein.Results：The positive expression rate of Oct4 protein was higher in hepatocellular carcinoma than that in the tumor adjacent tissues （75.9% vs 33.3%） （P 〈0.05）,which was positively correlated with tumor size and closely related to its vascular invasion and TNM satage （P 〈 0.05 ）.Conclusion：Oct4 protein is associated with tumor differentiation in hepatocellular carcinoma and may be taken as a valuable molecular marker in predicting the prognosis of hepatocellular carcinoma.
出处
《内蒙古医科大学学报》
2015年第6期506-509,共4页
Journal of Inner Mongolia Medical University
基金
内蒙古自然科学基金(81560384)
关键词
肝细胞癌
OCT4
蛋白
hepatocellular carcinoma
Oct4 protein
