摘要
目的:系统评价甲硝唑联合乳酸杆菌制剂治疗滴虫性阴道炎的疗效及不良反应。方法:计算机检索截止于2017年11月20日国内外使用乳酸杆菌制剂辅助治疗滴虫性阴道炎的随机对照试验(RCTs)文献,按照纳入和排除标准进行文献筛查、资料提取和质量评价后,最终纳入7篇RCTs研究,采用RevMan 5.3软件进行Meta分析。结果:与单用甲硝唑治疗的对照组相比,乳酸杆菌制剂联合甲硝唑治疗滴虫性阴道炎的总有效率(P=0.008)和治愈率(P<0.000 1)均较高,而总复发率(P=0.000 6)较低,差异均具有统计学意义。联合治疗组不良反应发生率较单用甲硝唑治疗组并未提高。结论:乳酸杆菌制剂辅助治疗滴虫性阴道炎可显著提高患者的总有效率和治愈率,明显降低复发率,且安全性好。
Objective:To assess the clinical effectiveness and untoward effects of metronidazole combined with lactobacillus lactis in treatment of trichomonal vaginitis.Methods:We searched randomized controlled trials(RCTs)about the lactobacillus lactis as adjuvant therapy for trichomonal vaginitis through the Chinese and English database before 20 th November 2017.The quality of the included and excluded trials was assessed.RevMan 5.3 software was used to conduct meta-analysis.Results:Compared to the metronidazole used alone,the total effective rate and cure rate were higher(P=0.008 and P<0.000 1),and recurrence rate was lower(P=0.000 6),when lactobacillus lactis was taken as adjuvant therapy for trichomonal vaginitis.In addition,the incidence of adverse effect showed no significant difference between the combined and metronidazole alone treatment group.Conclusion:Currently available evidence shows that the effect in the combined groups is better,and the recurrence rate is lower.
作者
周园红
罗幼珍
谢燕
刘强
Zhou Yuanhong;Luo Youzhen;Xie Yan;Liu Qiang(Yichang Central People's Hospital,The First College of Clinical Medical Science,China Three Gorges University,Yichang 443003,China)
出处
《巴楚医学》
2018年第2期60-64,100,共6页
Bachu Medical Journal
基金
国家自然科学基金青年项目(No:81402404
81403163)
宜昌市科技攻关项目(No:A14301-04
A14301-10)
中科院病毒学国家重点实验室开放研究基金项目(No:2017KF001)
关键词
乳酸杆菌制剂
滴虫性阴道炎
甲硝唑
有效性
安全性
lactobacillus lactis
trichomonal vaginitis
metronidazole
effectiveness
safety