维生素D水平与子宫内膜异位症相关性的Meta分析

The Relationship between Serum Vitamin D Level and Endometriosis:a Meta-Analysis

目的:探讨人血清维生素D水平与子宫内膜异位症发生的关系。方法:检索Pubmed、Embase、Cochrane、Medline、中国知网、维普及万方数据库,收集维生素D水平与子宫内膜异位症相关性的研究,应用STATA 12.0软件计算标准化均数差(SMD)及95%置信区间(95%CI),I^2检验评估研究间的异质性,采用敏感性分析和发表偏倚来分析异质性来源。结果:共纳入7篇文献,其中包含8个人血清维生素D水平与子宫内膜异位症相关性的研究。结果显示血清维生素D水平与子宫内膜异位症的发生无显著相关性(SMD=-0.40;95%CI:-1.13～0.34;P=0.29),Egger检验显示研究间无发表偏倚,敏感性分析显示结果稳定。结论:目前证据显示,人血清维生素D水平可能与子宫内膜异位症的发生无明显相关性。

Objective:To evaluate the relationship between serum vitamin D level and endometriosis.Methods:A systematic literature search of Pubmed,Embase,Corchrane,Medline,CNKI,CQVIP and Wan-Fang data was conducted to collect related articles.The standardized mean difference(SMD)and 95%confidence intervals(95%CI)were calculated using STATA 12.0 software.I^2 test was performed for heterogeneity assessment,and heterogeneous sources were analyzed by sensitivity analysis and publication bias.Results:There were 8 studies satisfying the inclusion criteria.The results indicated that serum vitamin D level was not associated with endometriosis(SMD=-0.40;95%CI:-1.13 to 0.34;P=0.29).There was no publication bias among these studies,and the result was stable.Conclusion:Current evidence shows that there may be no significant correlation between human serum vitamin D level and the occurrence of endometriosis.