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Triptolide抑制角膜免疫反应及TGF-β诱导角膜基质细胞胶原收缩实验研究 被引量:1

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摘要 雷公藤内酯醇(Triptolide,TP)是中药雷公藤的一种成分,已证实具有多种药理作用如抗炎、免疫调节等[1]。感染性角膜炎是世界范围内,尤其是发展中国家的主要致盲性眼病之一。TNF-α作为Thl细胞分泌产生的炎性细胞因子之一,与IL-2、IFN-1等共同介导细胞免疫[2,3],这些炎性因子及趋化因子可诱导炎性细胞对组织的浸润功能。
出处 《中国实验诊断学》 2016年第1期19-21,共3页 Chinese Journal of Laboratory Diagnosis
基金 国家自然科学基金(81300727)资助 吉林大学白求恩B计划项目(吉林大学基本科研业务费2012230)
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参考文献11

  • 1Ranyia M, Xianxi W, Hui Ge, et al. Triptolide induces anti-in- flammatory cellular responses[J]. Am J Transl Res, 2009,1 (3) : 267.
  • 2Kumagai N,Fukuda K,Ishimura Y,et al. Synergistic induction of eotaxin expression in human keratocytes by TNF-alpha and IL-4 or IL-13[J]. Invest Ophthalmol Vis Sci, 2000,41 : 1448.
  • 3Seung Hoon Lee,Kyoung Woo Kim,Kyong-Mi Min,et al. Angio- genin Reduces Immune Inflammation via Inhibition of TANK- Binding Kinase 1 Expression in Human Corneal Fibroblast Cells [J]. Mediatorslnflamm, 2014,861435.
  • 4Azueena Kakazu, Jiucheng He,Sachidananda Kenchegowda, et al. BazanLipoxin A4 inhibits platelet-activating factor inflammatory response and stimulates corneal wound healing of injuries that compromise the stroma[J]. Exp Eye Res, 2012,103 : 9.
  • 5Sharon Altmann, Megan Toomey, Brittany Nesbit, et al. Kinetics of Immune Cell Infiltration in Vaccinia Virus Keratitis[J]. Invest Ophthalmol Vis Sci, 2010,51 (9) : 4541.
  • 6Steven E. Wilson Corneal myofibroblast biology and pathohiolo- gy:Generation,persistenee,and transparency[J]. Exp Eye Res, 2012,99(1) :78.
  • 7Seung Hoon Lee,Kyoung Woo Kim,Kyong-Mi Min,et al. Angio- genin Reduces Immune Inflammation via Inhibition of TANK- Binding Kinase 1 Expression in Human Corneal Fibroblast Cells [J]. Mediators Inflamm, 2014,861435.
  • 8Guo-Ling Chen,Jing-Jing Zhang,Xin Kao,Lu-Wan Wei,Zhi-Yu Liu.Emodin ameliorates lipopolysaccharides-induced corneal inflammation in rats[J].International Journal of Ophthalmology(English edition),2015,8(4):665-669. 被引量:7
  • 9Milani BY, Milani FY, Park DW, et al. Rapamycin Inhibits the Production of Myofibrohlasts and Reduces Corneal Scarring Af- ter Photorefraetive Kerateetomy[J]. Invest Ophthalmol Vis Sci, 2013,54(12) : 7424.
  • 10Long Shi, Yuan Chang, Yongmei Yang, et al. Activation of J NK Signaling Mediates Connective Tissue Growth Factor Expres- sion and Scar Formation in Corneal Wound Healing[J]. PLoS One, 2012,7 (2) : e32128.

二级参考文献18

  • 1Nagla A. El-Shitany,Eman A. El-Bastawissy,Karema El-desoky.Ellagic acid protects against carrageenan-induced acute inflammation through inhibition of nuclear factor kappa B, inducible cyclooxygenase and proinflammatory cytokines and enhancement of interleukin-10 via an antioxidant mechanism[J]. International Immunopharmacology . 2014 (2)
  • 2Ang Li,Lei Dong,Mei‐Li Duan,Kai Sun,Yu‐Ying Liu,Ming‐Xia Wang,Jing‐Na Deng,Jing‐Yu Fan,Bao‐En Wang,Jing‐Yan Han.Emodin Improves Lipopolysaccharide‐Induced Microcirculatory Disturbance in Rat Mesentery[J]. Microcirculation . 2013 (7)
  • 3Chih-Feng Chian,Chi-Huei Chiang,Chiao-Hui Chuang,Shiou-Ling Liu.Inhibitor of nuclear factor-κB, SN50, attenuates lipopolysaccharide-induced lung injury in an isolated and perfused rat lung model[J]. Translational Research . 2013
  • 4Nilesh M. Kalariya,Mohammad Shoeb,Aramati B.M. Reddy,Rahul Sawhney,Kota V. Ramana.Piceatannol Suppresses endotoxin-induced ocular inflammation in Rats[J]. International Immunopharmacology . 2013
  • 5Megan E. B. Foldenauer,Sharon A. McClellan,Ronald P. Barrett,Yunfan Zhang,Linda D. Hazlett.Substance P Affects Growth Factors in Pseudomonas aeruginosa–Infected Mouse Cornea[J]. Cornea . 2012 (10)
  • 6Wanwen Lan,Andrea Petznick,Suzi Heryati,Maula Rifada,Louis Tong.Nuclear Factor-κB: Central Regulator in Ocular Surface Inflammation and Diseases[J]. The Ocular Surface . 2012 (3)
  • 7GuoquanMeng,YiyaoLiu,ChangchunLou,HongYang.Emodin suppresses lipopolysaccharide‐induced pro‐inflammatory responses and NF‐κB activation by disrupting lipid rafts in CD14‐negative endothelial cells[J]. British Journal of Pharmacology . 2010 (7)
  • 8Zhu X,Zeng K,Qiu Y,et al.Therapeutic effect of emodin on collagen-induced arthritis in mice. Inflammation . 2013
  • 9HUANG Y,LU Y,ZHANG L,et al.Perineural dexmedetomidine attenuates inflammation in rat sciatic nerve via the NF-κB pathway. Int J Mol Sci . 2014
  • 10Yan Sun,Mausita Karmakar,Sanhita Roy.TLR4 and TLR5 on Corneal Macrophages Regulate Pseudomonas aeruginosa Keratitis by Signaling through MyD88-Dependent and -Independent Pathways. JOURNAL OF IMMUNOLOGY . 2010

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