美沙拉嗪联合双岐杆菌三联活菌治疗溃疡性结肠炎的疗效及对氧化应激、炎症因子的影响

Clinical effect and effect of mesalazine combined with bifico on oxidative stress and cytokines in patients with ulcerative colitis

目的:探讨美沙拉嗪联合双岐杆菌三联活菌治疗溃疡性结肠炎(UC)的疗效及对氧化应激、炎症因子的影响。方法:将92例于我院进行治疗的UC患者随机分为观察组和对照组,各46例。观察组行美沙拉嗪联合双岐杆菌三联活菌进行治疗,对照组行美沙拉嗪单药治疗,两组治疗时间均为两个月。比较两组疗效,测定两组氧化应激标志物丙二醛(MDA)、超氧化物歧化酶(SOD)水平及炎症因子白介素10(IL-10)、肿瘤坏死因子(TNF-α)水平并进行比较。结果:治疗后观察组的总有效率明显高于对照组,差异具有统计学意义(P<0.05);与治疗前相比,两组MDA、TNF-α水平均明显下降,SOD、IL-10水平均明显升高,差异具有统计学意义(P<0.05);治疗后,观察组较对照组MDA、TNF-α水平下降更明显,SOD、IL-10水平升高更明显,差异具有统计学意义(P<0.05)。结论:美沙拉嗪联合双岐杆菌三联活菌治疗溃疡性结肠炎的疗效显著,可有效调节氧化应激和炎症因子水平。

Objective： To investigate the effect of mesalazine combined withbifico on oxidative stress and cytokines in patients with ulcerative colitis. Methods： A total of 92 cases with ulcerative colitis were randomly divided into observation group （46 cases） and control group （46 cases） ： observation group （mesalazine ＋ bifico）, control group （mesalazine）. Levels of malondialdehyde （MDA）, superoxide dismutase （SOD）, TNF-a （tumor necrosis factor-a） and Interleukin-10 （IL-10） were tested and compared in patients with ulcerative colitis. Results.. Total effective rate was significantly increased after treatment in observation group （P〈0.05） ： MDA, TNF-α were significantly reduced and SOD, IL-10 were significantly increased after treatment in two groups （P〈0.05） ; MDA, TNF-a were more significantly reduced and SOD, IL-10 were more significantly increased in observation group （P〈0.05）. Conclusions： Mesalazine combine with bifico treatment has reliable curative effect in ulcerative colitis patients,which can regulate oxidative stress and eytokines.