热化疗治疗晚期非小细胞肺癌的疗效观察

OBSERVATION ON THE THERAPEUTIC EFFECT OF THE THERMOCHEMOTHERAPY ON ADVANCED NON SMALL CELL LUNG CANCER

目的观察热化疗治疗晚期非小细胞肺癌的近期疗效及毒副作用。方法将该院有明确病理诊断的112例晚期非小细胞肺癌患者随机分为二组,采用单纯化疗与热化疗两种方案对患者进行治疗,共计2周期,对近期疗效及毒副作用进行分析。结果经过统计分析可以得出,热化疗组的RR(32.1%)明显高于单纯化疗组(21.4%)、DCR(78.6%)明显高于单纯化疗组(60.7%),且差异有统计学意义(P=0.030,P=0.022)。二组的毒副作用发生率差异无统计学意义(P>0.05)。结论热化疗治疗晚期非小细胞肺癌近期疗效显著,毒副作用不增加,值得临床推广。

Objective To observe the efficacy and toxicity of the thermochemotherapy in treating the advanced non smal cell lung cancer.Methods The 112 patients diagnosed with advanced non small cell lung cancer in author＇s hospital were randomly divided into two groups.Two methods of the pure chemotherapy and thermochemotherapy were adopted to treat the patients for two periods,and then the reactions to the efficacy and toxicity were analyzed.Results By statistical analysis,the conclusion was that the RR（32.1%）and DCR（78.6%）of thermochemotherapy group were obviously higher than the RR（21.4%）and the DCR（60.7%）of group pure chemotherapy,the differences were of great statistically significance of（P=0.030,P=0.022）.The incidence of toxic and side effect between the two groups had no significant difference（P〉0.05）.Conclusion The short-term effect on the thermochemotherapy in treating the advanced non smal cell lung cancer is obvious.The toxic and side effects has no increase.It is worth clinic spreading.