口腔幽门螺杆菌感染与胃幽门螺杆菌感染以及牙周炎的相关性研究

The correlation of Helicobacter pylori infection in the oral cavity and in the stomach and periodontitis

目的探讨口腔内幽门螺杆菌(Helicobacter pylori,Hp)感染与胃内Hp感染以及与牙周炎的关系.方法通过^(13)C尿素呼气试验检测法和幽门螺杆菌唾液测试法对120例有消化道症状的患者进行胃内和口腔内Hp的检测,并对患者进行牙周检查,分析口腔Hp感染与胃Hp感染的关系以及与牙周炎的关系.结果 120例有消化道症状的患者中,胃Hp阳性患者口腔Hp的阳性率为87.7%,胃Hp阴性患者口腔Hp的阳性率为42.6%,两者差异有统计学意义(χ~2=27.715,P<0.001);牙周正常者、轻度牙周炎患者、中度牙周炎患者和重度牙周炎患者中口腔Hp感染的阳性率分别为45.5%、55.3%、81.5%和82.4%,差异有统计学意义(χ~2=11.711,P<0.01).结论口腔Hp感染与胃Hp感染密切相关,可能是胃Hp感染的来源;口腔Hp感染也与牙周炎的严重程度相关.

Objective To investigate the correlation of Helicobacter pylori infection in the oral cavity and stomach, and correlation of Helicobacter pylori infection in the oral cavity and periodontitis. Methods 120 patients with chronic gastric diseases received ^13C-urea breath test, Hp saliva test and periodontal examination. The correlation of Helicobacter pylori infection in the oral cavity and stomach, and ton＇elation of Helicobacter pylori infection in the oral cavity and periodontitis were analyzed. Results The experiments showed that the positive rate of Hp in the oral cavity was 87.7% in stomach-Hp-positive patients, while the positive rate of Hp in the oral cavity was only 42.6% in stomach-Hp-negative patients, which was significantly lower （P 〈0. 001）. The positive rate of Hp in the oral cavity in patients with normal periodontium, mild periodontitis, moderate periodontitis and severe periodontitis were 45.5%, 55.3%, 81.5% and 82.4% separately, and the difference was statistically significant （ P 〈 0.01 ）. Conclusion Hp infection in the oral cavity is closely related to its infection in the stomach, and is also related to the severity of periodontitis.