拉贝洛尔联合硫酸镁对妊娠期高血压孕妇血清炎性因子、肾功能及分娩结局的影响

Influence of Labetalol Combined with Magnesium Sulfate Used in Gestational Hypertension of Pregnant Women on Serum Inflammatory Factor,Kidney Function and Birth Outcomes

目的探讨拉贝洛尔联合硫酸镁用于妊娠期高血压对孕妇血清高迁移率蛋白-1(HMGB1)、同型半胱氨酸(HCY)及半胱氨酸蛋白酶抑制剂C(Cys C)水平及分娩结局的影响。方法将2012年3月至2014年12月就诊的200例患者随机分为试验组和对照组,各100例。试验组患者给予拉贝洛尔联合硫酸镁治疗,对照组患者仅给予硫酸镁治疗。结果治疗后,试验组血清HMGB1,HCY和Cys C水平明显低于对照组,自然顺产率高于对照组,而剖宫产发生率、产后出血发生率、产后感染发生率及产后并发症发生率亦低于对照组,差异均有统计学意义(P<0.05)。结论拉贝洛尔联合硫酸镁治疗妊娠期高血压可显著降低患者血清HMGB1,HCY,Cys C水平,改善分娩结局,值得推广。

Objective To discuss the efficacy of labetalol combined with magnesium sulfate used in gestational hypertension of pregnant women on serum HMGB1, HCY and Cys C levels and birth outcomes. Methods 200 cases of patients from March 2012 to December2014 were randomly divided into experimental group and control group,100 cases in each group. The experimental group was given labetalol combined with magnesium sulfate,and the control group was only treated with magnesium sulfate. Results The serum HMGB1,HCY and Cys C levels of the experimental group was significantly lower than those of the control group,the natural birth rate was higher than that of the control group,and the cesarean delivery rate,the incidence rate of postpartum hemorrhage,postpartum infection rate and postpartum complications occurrence rate were also lower than those of the control group（ P〈0. 05）. Conclusion Labetalol combined with magnesium sulfate in the treatment of pregnancy induced hypertension can significantly reduce the patients serum HMGB1, HCY,Cys C level,and improve birth outcomes,which is worthy of clinical promotion.