甲钴胺联合硫辛酸治疗2型糖尿病合并周围神经病变40例

Methycobal Combined with Lipoic Acid for Treating Patients with Type-2 Diabetes Complicated with Diabetic Peripheral Neuropathy in 40 Cases

目的观察甲钴胺联合硫辛酸治疗2型糖尿病合并周围神经病变的疗效。方法选取2014年1月至2015年5月医院收治的80例2型糖尿病合并周围神经病变患者,根据随机数字法分为对照组(甲钴胺)和观察组(甲钴胺联合硫辛酸),各40例。结果与对照组相比,观察组总有效率明显提高(90.00%比72.50%,P<0.05);观察组正中神经、腓总神经的运动神经和感觉神经的传导速度均明显增快(P<0.05);观察组症状总评分(TSS)[(4.2±0.9)分比(6.3±1.2)]分及疼痛视觉模拟评分(VAS)[(4.3±0.5)分比(5.4±0.7)分]均明显降低(P<0.05)。结论甲钴胺联合硫辛酸能明显提高2型糖尿病合并周围神经病变的临床疗效,并显著改善周围神经病变,值得推广。

Objective To study the efficacy of methycobal combined with lipoic acid for patients with type- 2 diabetes complicated with diabetic peripheral neuropathy. Methods 80 cases of patients with type- 2 diabetes complicated with diabetic peripheral neuropathy from January 2014 to May 2015 were randomized into the control group（ methycobal） and the observation group（ methycobal combined with lipoic acid）,40 cases in each group. Results Compared with the control group,the total effective rate was significantly increased in the observation group（ 90. 00% vs 72. 50%, P〈0. 05）; the movement and sensory nerve conduction velocities were significantly increased on post- treatment in the observation group（ P〈0. 05）; after treatment,the TSS scores of the observation group and the contorl group were（ 4. 2 ± 0. 9 vs 6. 3 ± 1. 2） and the VAS scores were（ 4. 3 ± 0. 5 vs 5. 4 ± 0. 7）,which had significantly difference（ P〈0. 05）.Conclusion The treatment of methycobal combined with lipoic acid can significantly increase the clinical efficacy for patients with type- 2 diabetes complicated with diabetic peripheral neuropathy, can obviously improve the peripheral neuropathy symptoms, and is worthy of clinical promotion.