绝经后骨质疏松症的不同治疗方法及疗效对比

Clinical Treatment and Efficacy Analysis of Postmenopausal Osteoporosis

目的探讨绝经后骨质疏松症(Ⅰ型原发性骨质疏松症)的不同临床治疗方法及疗效。方法将2013年3月至2014年9月医院收治的160例绝经后骨质疏松症患者分为两组,各80例。观察组采用双膦酸盐+骨营养剂治疗,对照组采用性激素替代疗法+骨营养剂治疗,两组均同时配合康复锻炼。结果观察组患者跌倒风险指数为(1.24±0.45)分,骨密度为(-1.99±0.67)mg/cm3,治疗总有效率为75.00%,均明显优于对照组的(1.83±0.64)分、(-2.15±0.58)mg/cm3、53.75%(P<0.05);同时生活质量各项评分也均优于对照组(P<0.05)。结论对绝经后骨质疏松症的患者,应用双膦酸盐+骨营养剂及性激素替代疗法+骨营养剂同时配合对症治疗与康复训练的综合疗法后,患者骨密度均明显增高,跌倒风险均降低,可有效提高生活质量。

Objective To investigate the clinical treatments of postmenopausal osteoporosis（ type I primary osteoporosis） and compare the efficacy of different treatment options. Methods 160 patients with postmenopausal osteoporosis were treated with different treatment options in the hospital from March 2013 to September 2014, 80 patients of the observation group were given bisphosphonate ＋ bone nutrients, while 80 patients of the control group were given hormone replacement therapy ＋ bone nutrients. Results The fall risk index was（ 1. 24 ± 0. 45） points, bone mineral density was（- 1. 99 ± 0. 67） mg / cm3, and the overall response rate was 75. 00% in the observation group,which were obviously better than（ 1. 83 ± 0. 64） points,（- 2. 15 ± 0. 58） mg / cm3,and 53. 75% of the control group,and the quality of life scores in the observation group was also better than that of the control group（ P〈0. 05）. Conclusion The combination of bisphosphonate or hormone replacement therapy ＋ bone nutrients, in conjunction with symptomatic treatment and rehabilitation training,can obviously increase bone mineral density,decrease fall risk,and improve the quality of life in postmenopausal osteoporosis patients.