吸入用布地奈德混悬液联合硫酸镁治疗新生儿胎粪吸入综合征30例

Budesonide Suspension for Inhalation Combined with Magnesium Sulfate for Treating Neonatal Meconium Aspiration Syndrome in 30 Cases

目的观察吸入用布地奈德混悬液联合硫酸镁治疗新生儿胎粪吸入综合征临床疗效,并分析其安全性。方法选取60例接受治疗的新生儿胎粪吸入综合征患儿,根据不同治疗方法分为两组,各30例。对照组给予常规治疗,观察组在常规治疗基础上加用吸入用布地奈德混悬液、硫酸镁联合治疗。结果观察组患儿总有效率为93.33%,明显优于对照组的70.00%(P<0.05);观察组的呼吸困难缓解时间为(3.39±1.18)d,湿罗音消失时间为(6.71±1.09)d,发绀消失时间为(1.19±0.50)d,血氧饱和度恢复时间为(1.08±0.82)d,吸痰次数为(3.17±1.06)次,住院时间为(8.09±2.27)d,均明显优于对照组的(4.63±1.52)d,(8.42±1.68)d,(2.43±0.57)d,(1.82±0.88)d,(4.61±1.49)次和(9.84±2.51)d(P<0.05);观察组并发症发生率为6.67%,明显低于对照组的33.33%(P<0.05)。结论采用吸入用布地奈德混悬液联合硫酸镁辅助治疗新生儿胎粪吸入综合征,临床效果优于常规治疗,并可有效改善患儿临床症状,安全、可靠,值得临床推广。

Objective To observe the clinical efficacy of Budesonide Suspension for Inhalation combined with magnesium sulfate in treating neonatal meconium aspiration syndrome,and to analyze the safety of the treatment. Methods 60 cases neonates with meconium aspiration syndrome in the hospital were selected and divided into two groups according to the different treatment methods,30 cases in each group. The control group was treated with conventional therapy, and on the basis of the control group, the observation group was given Budesonide Suspension for Inhalation combined with magnesium sulfate. Results The total effective rate of the observation group was 93. 33%, which was obviously better than 70. 00% of the control group（ P〈0. 05）. The observation group＇s dyspnea remission time was（ 3. 39 ± 1. 18） d, the auscultation disappearance time was（ 6. 71 ± 1. 09） d, cyanosis disappearance time was（ 1. 19 ± 0. 50） d time, SP〈02 recovery time was（ 1. 08 ± 0. 82） d, sputum suction times was（ 3. 17 ± 1. 06） times, and hospitalization time was（ 8. 09 ±2. 27） d,which were significantly better than（ 4. 63 ± 1. 52） d,（ 8. 42 ± 1. 68） d,（ 2. 43 ± 0. 57） d,（ 1. 82 ± 0. 88） d,（ 4. 61 ± 1. 49） times and（ 9. 84 ± 2. 51） d of the control group（ P〈0. 05）; the incidence rate of complications in the observation group was 6. 67%,which was significantly lower than 33. 33% of the control group（ P〈0. 05）. Conclusion Budesonide Suspension for Inhalation combined with magnesium sulfate in treating neonatal meconium aspiration syndrome has superior outcome compared with conventional treatment,can effectively improve the clinical symptoms of children,is safe and reliable,which is worthy of clinical promotion.