βB_2晶状体蛋白与白内障

Beta B_2-crystallin and cataract

βB_2晶状体蛋白是β族晶状体蛋白中含量最多的一种,在维持晶状体的透明性和屈光性中起着重要作用。βB_2晶状体蛋白异常可能与多种类型白内障的形成有关。近年来,CRYBB_2基因突变所致白内障的机制成为研究的热点。本文将对βB_2晶状体蛋白的结构、功能、相关突变、与各类型白内障关系做一综述。

Beta B2-crystallin is the most abundant crystallin in theβ- family,which plays an important role in the maintenance of the lens transparency and refraction.The abnormal of beta B2-crystallin may be associated with the formation of various types of cataract.In recent years,the mechanism of cataract which caused by the related mutations of CRYBB2 gene is becoming a hot spot of research.This article summarized the structure,function and mutation of beta B2-crystallin and its relations with various types of cataract.