自体角膜缘干细胞移植治疗翼状胬肉取不同经线宽度植片的疗效比较

Curative effect comparison of autologous corneal limbal stem cell transplantation with grafts having different longitude widths for pterygium

目的：比较自体角膜缘干细胞移植治疗翼状胬肉取不同经线宽度结膜植片的疗效。方法：对182例252眼初发翼状胬肉行翼状胬肉切除联合角膜缘干细胞移植,按术中结膜植片的经线宽度分为两组：小植片组86例110眼,行干细胞移植时取结膜植片经线宽度为3mm;大植片组96例142眼,取结膜植片经线宽度为5mm,术后1、6、12、24mo随访,观察两组的复发率统计分析其差异。结果：术后早期（1~12mo）小植片组与大植片组复发率比较无统计学意义（P〉0.05）,术后远期（24mo）复发率差异有统计学意义（P〈0.05）。结论：翼状胬肉切除联合自体角膜缘干细胞移植治疗翼状胬肉,较大经线宽度的结膜植片可以降低远期的复发率。

AIM：To compare curative effect of autologous corneal limbal stem cell transplantation with grafts having different longitude widths for pterygium.METHODS：A total of 182 patients（252 eyes） with initial pterygium accepted pterygium resection combined with corneal limbal stem cell transplantation,all of which were divided into two groups according to longitude width of conjunctival graft during the operations.When performing stem cell transplantation,patients with conjunctival grafts being taken out with longitude widths by 3mm had been classified into small graft group（n = 86,110 eyes）,while those with longitude widths by 5mm had been classified into large graft group（n = 96,142 eyes）.We observed and statistically analyzed the recurrence rates of the two groups at 1,6,12 and 24 mo after operations during follow-up period.RESULTS：There was no significant difference of recurrence rate between the small graft group and large graft group in early phase（1-12mo） after transplantation（P〉 0.05）,while there was statistically significant difference in long term（24mo） after transplantation（P〈0.05）.CONCLUSION：Conjunctival graft with larger size of longitude width is in favor of reducing the long term recurrence risk after pterygium resection combined with autologous corneal limbal stem cell transplantation.