植物生物反应器在分子医药农业中的应用

Progress of Plant as Bioreactor in Molecular Pharming

植物生物反应器作为分子医药农业的核心内容,与动物反应器和微生物反应器相比具有操作简便、成本低、规模化、周期短等优势,越来越多地被人们认识和应用。阐述了植物生物反应器转化载体构建和基因优化的方法、常用的植物受体种类,以及植物表达系统类型三个方面的研究进展。随着药用蛋白需求量的大幅度增加,植物生物反应器以其低成本的优势将显示出广阔的应用前景。

Using plant as bioreactor to produce various valuable proteins or peptides is the central part of molecular pharming.This method is more and more used because of its advantages such as simple operation,low cost,large scale planting and short period compared with animal and microbe bioreactor.The common optimization methods of vector construction and foreign gene,variety of plant acceptor and the different expression systems of plant bioreactor were reviewed.As the increasing demand of biopharmaceuticals,there is a great perspective of plant bioreactor to be used in molecular pharming in the future.