氟哌啶醇与利培酮改善痴呆患者行为症状和精神状态的临床实效性探讨

The exploration of clinical effectiveness of haloperidol and risperidone on improving behavioral and psychological symptoms of dementia

目的观察并探讨氟哌啶醇与利培酮改善痴呆患者行为症状和精神状态(behavioural and psychological symptoms of dementia,BPSD)的临床实效性。方法选择2011-08-2013-10我院接诊的痴呆患者80例,随机分为观察组和对照组,观察组40例使用利培酮(risperidone,RPD)治疗,对照组使用氟哌啶醇(haloperidol,HPL)治疗。以PANSS-EC和PANSS评定量表作为主要疗效评价指标。结果 2组给药6周PANSS总分和PANSS-EC分比较差异无统计学意义(P>0.05)。而给药6周后与治疗前2组比较差异均具有统计学意义(P<0.05)。用药后观察组、对照组锥体外系不良反应发生率分别为42.5%、67.5%,差异有统计学意义(P<0.05)。观察组有效率为87.5%,对照组为65.0%,2组比较差异有统计学意义(P<0.05)。结论RPD口服对改善BPSD与HPL疗效相当,但RPD的临床实效性更好,锥体外系不良反应发生率低,值得临床推广应用。

Objective To observe and explore the effect of haloperidol and risperidone on improving behavioral and psychological symptoms of dementia（BPSD）.Methods Eighty cases with dementia in the hospital from August 2011 to October2013were selected,who were randomly divided into observation group treated by risperidone and control group treated with haloperidol,40 patients in each group.PANSS-EC and PANSS Rating Scale were used as the primary methods to effciently evaluate the efficacy of two groups.Results After 6-week therapy,no significant difference was observed in two groups in terms of PANSS total score and PANSS-EC scores（P〈0.05）between two groups,we found statistical difference when compared with before treatment in both groups（P〈0.05）.The incidence of adverse reactions after treatment of both groups was recorded as follows：42.5%in the observation group,67.5%in the control group,with a statistically significant difference（P〈0.05）.Follow-up administration after 6-week treatment showed that the effective rate of observation group and control group was 87.5% and 65.0%,respectively.Conclusion Haloperidol and risperidone have equivalent therapeutic effect on BPSD patients,but risperidone may achieve better clinical effectiveness with less adverse events,which should be worthy of further application in clinicl.