健康大学生血清血管紧张素Ⅱ、一氧化氮、同型半胱氨酸水平的四时观测及其与神经质、生活事件的关联性研究

The Serum Levels of AT-Ⅱ,NO and Hcy of Healthy University Students in Four Seasons and Their Correlation With Neuroticism and Life Events

目的了解健康大学生血清血管紧张素Ⅱ(AT-Ⅱ)、一氧化氮(NO)、同型半胱氨酸(Hcy)水平的四时变化规律,探讨其与神经质及生活事件的关联性。方法选取2011年12月—2012年10月北京、山东、山西三地中医药大学大二年级身心健康的在校学生308名,使用自拟健康状况调查问卷、艾森克人格问卷简式量表中国版(EPQ-RSC)、青少年生活事件自评量表进行身心健康状况调查,分别在冬至、春分、夏至、秋分4个节气前后3 d进行血清AT-Ⅱ、NO、Hcy水平检测,分析不同神经质及生活事件健康大学生四时血清AT-Ⅱ、NO、Hcy水平。结果308名大学生中,秋分节气北京1名女大学生因病休学未继续参与调查,因此307名大学生进入统计。根据EPQ-RSC神经质得分及生活事件得分进行分组,分为低神经质低生活事件组(A组,n=41)和高神经质高生活事件组(B组,n=34)。健康大学生四时血清AT-Ⅱ、NO、Hcy水平间差异均有统计学意义(P<0.05),其中血清AT-Ⅱ水平冬至最高、秋分最低,血清NO水平冬至最高、夏至最低,血清Hcy水平春分最低、夏至最高。B组夏至血清AT-Ⅱ水平低于A组,血清NO水平高于A组,差异均有统计学意义(P<0.05);两组四时血清Hcy水平间差异均无统计学意义(P>0.05);两组四时血清AT-Ⅱ、NO、Hcy水平变化幅度和趋势均不同;B组出现了更多的郁闷、善太息等情绪及躯体不适,类似中医肝疏泄不足的表现。结论健康人群血清AT-Ⅱ、NO、Hcy水平有四时变化的规律;3个指标的血清水平与神经质、生活事件密切相关;从中医理论分析,其可能与肝的疏泄功能是否良好相关。

Objective To investigate the changing laws of serum levels of AT-Ⅱ,NO and Hcy of healthy university students in four seasons,and to study the correlation between the three indicators and neuroticism and life events.Methods From December 2011 to October 2012, we enrolled 308 healthy sophomore students in the universities of traditional Chinese medicine in Beijing,Shandong and Shanxi.Self- designed questionnaire of health condition,EPQ-RSC and self- administrated scale of adolescent life events were used to conduct survey on physical and psychological health condition.Three days before and after winter solstice, spring equinox, summer solstice and autumn equinox, the levels of serum AT-Ⅱ, NO and Hcy were measured,and the levels of healthy university students with different conditions of neuroticism and life events were analyzed.Results At last,307 university students were included after the exclusion of one female student in Beijing who didn＇t finish the survey due to sick rest.According to the score of neuroticism in EPQ-RSC and life event,the students were divided into group of low neuroticism and low life event（ group A,n = 41） and group of high neuroticism and high life event（ group,n = 34）.These healthy students were significantly different in the levels of serum AT-Ⅱ,NO and Hcy（ P〈0.05）; serum AT-Ⅱ level was highest in winter solstice and lowest in autumn equinox; serum NO level was highest in winter solstice and lowest in summer solstice; serum Hcy level was lowest in spring equinox,and was highest in summer solstice.Group B was lower in serum AT-Ⅱlevel and was higher in serum NO level than group A in summer solstice（ P〈0.05）; the two groups were not significantly different in serum Hcy level in four seasons（ P〉0.05）; the two groups were different in the amplitude of variation and changing trend of the levels of AT-Ⅱ, NO and Hcy in the four seasons; B group had more cases with emotions like depression and preference for sighing and body discomfort,which resembled the symptoms of insufficient liver catharsis in TCM.Conclusion The serum levels of AT-Ⅱ,NO and Hcy have changing laws with the four seasons.The three indicators have close correlation with neuroticism and life events.From the prospective of TCM,the phenomenon may be related with the catharsis function of liver.