摘要
目的探讨纤维蛋白原基因FGG 10034 C>T基因多态性与缺血性脑卒中的关联性,寻找缺血性脑卒中的遗传易感性因素,以期从分子水平阐明缺血性脑卒中的发病机制。方法回顾性收集100例临床诊断为缺血性脑卒中(IS)的患者资料作为病例组及101例健康查体者的临床资料作为对照组,应用聚合链反应-限制性片段长度多态性(PCR-RFLP)进行基因多态性分析。结果 FGG 10034 C>T位点T/T基因型及T等位基因在缺血性脑卒中组出现的频率(分别为14%、33.5%)明显高于对照组,差异有统计学意义(P<0.05)。结论纤维蛋白原基因FGG 10034 C>T位点与缺血性脑卒中有关联,可能是一个遗传学的危险因素。
Objective To explore the relationship between the polymorphism of fibrinogen gene FGG 10034 C 〉 T and ischemic stroke, looking for genetic susceptibility factors of ischemic stroke, in order to elucidate the pathogenesis of ischemic stroke based on molecular level. Methods Fibrinogen gene FGG 10034 C 〉 T polymorphism was determined by PCR-RFLP in 100 cases of ischemic stroke and 100 controls selected form Binzhou medical school affiliated hospital. Results The frequencies of FGG 10034 T/T genotype and T allele in the groups of ischemic stroke group were 14.0%and 33.5%, which were significantly higher than control group （P〈 0.05）. Conclusion There is correlation between the fibrinogen FGG 10034 C〉T polymorphism and ISFGG 10034 C〉T may be a gnetic risk factors of stroke.
出处
《当代医学》
2016年第4期20-21,共2页
Contemporary Medicine
基金
滨州医学院校级科技计划项目(BY 2011 KZ 08)
