静电纺丝法制备温敏性PNIPAAm/EC复合纳米纤维

Electrospinning of PNIPAAm/EC thermosensitive nanofiber

采用静电纺丝技术成功制备出温敏性PNIPAAm/EC复合纳米纤维并使用扫描电子显微镜（SEM）、傅里叶变换红外光谱（FT-IR）、凝胶渗透色谱（GPC）及接触角（CA）对复合纤维进行表征。结果表明：制备的复合纳米纤维直径为360~400nm,当纺丝液中聚N-异丙基丙烯酰胺（PNIPAAm）与乙基纤维素（EC）的质量比为1∶2时,纤维形貌最佳,且随着EC含量增加,纤维直径减少;当温度为25℃时,材料表现为较强的亲水性,当温度为40℃时,材料疏水性明显增强。实验结果可以证明PNIPAAm/EC复合纳米纤维具有良好的温敏性能,可应用为温敏性智能型载药材料。

The thermoresponsive nanofibers poly（N-isopropylacrylamide）/ethylcellulose（PNIPAAm/EC）were successfully fabricated through electrospinning.The prepared PNIPAAm/EC nanofibers were characterized by scanning electron microscopy（SEM）,foruier-transform infrared spectroscopy（FT-IR）,gel permeation chromatography（GPC）and contact angle（CA）.The SEM images showed that the diameters of nanofibers were 360~400nm.Moreover,with the increasing mass ration of EC in the nanofibers,the diameters of nanofibers decreased gradually.Furthermore,when the mass ratio of PNIPAAm to EC was 1∶2,the morphology of nanofibers were better than other samples.The CAs of PNIPAAm/EC nanofibers film was measured in 25℃and 40℃.As a result,the nanofibers switched from hydrophilicity to hydrophobicity when the temperature increased from 25℃to 40℃.The aboved results demonstrated that the nanofibers had promising thermosensitivity and can be used as thermoresponsive carriers for controlled drug delivery.