有机锡配合物抗癌活性的研究

Study on antitumour activity of organotin carboxylate [(Ph)_3Sn(Ph_2CONHCOO)]

目的合成有机锡羧酸酯化合物并测试抗癌活性。方法以Ph2CONHCOOH为配体,与Ph3Sn OH合成[(Ph)3Sn(Ph2CONHCOO)](化合物1);通过MTT法测定化合物1对MCF-7细胞的抗癌活性。结果小剂量的化合物1便可以对MCF-7细胞产生很高的抗癌活性。结论化合物1具有作为抗癌药物的潜质。

Objective To synthesize an organotin carboxylate and observe its antitumour activity. Methods Com-plex One was synthesized by Ph2 CONHCOOH and Ph3 SnOH,and its antitumour effect against MCF-7 was tested by MTT. Results The MTT results showed that complex one in micro-dose possessed high antitumour activity against MCF-7. Conclusion The complex one has the potential to be anti-cancer drug.