氨酚待因片(Ⅱ)处方工艺研究及溶出度考察

Formulation technology and Dissolution of Paracetanmol and Codeine Phosphate Tablets(Ⅱ)

目的:筛选优化氨酚待因片(Ⅱ)的处方工艺。方法:通过处方设计筛选填充剂、粘合剂和崩解剂,以湿法制粒制备氨酚待因片(Ⅱ),以市售制剂在不同介质中的溶出曲线为指标,确定处方工艺。结果:采用优化处方工艺制备的氨酚待因片(Ⅱ)的溶出行为与市售制剂基本一致。结论:处方工艺合理,达到设计要求。

Objective： To optimize the formulation and technology of Paracetanmol and Codeine Phosphate Tablets（Ⅱ）. Methods：Screening fillers, adhesives and disintegrants, and wet granulation technology were finalized by comparing the tablets performance to the dissolution curves of the tablets in the market in different mediums as evaluation index. Results： Dissolution of the tablets prepared by the optimal formulation and technology is similar to the performance of the tablets in the market. Conclusions： The Paracetanmol and Codeine Phosphate Tablets（Ⅱ）prepared by optimized formulation technology are reasonable, and achieve the design requirements.