视网膜母细胞瘤蛋白基因在喉癌研究中的进展

Research development ofRb gene in laryngeal carcinoma

喉癌是头颈部常见的恶性肿瘤，其发生和发展是多基因（如Rb、C—MYC、MDM2、PTEN等喉癌相关基因）、多通路共同参与的结果。其中视网膜母细胞瘤蛋白（retinoblastomaprotein，Rb）基因是人类发现的第一个肿瘤抑癌基因，主要通过调控细胞周期发挥抑癌作用。随着对Rb基因在肿瘤中研究的深入，发现Rb基因与喉癌的侵袭、转移密切相关，而喉癌局部复发或转移决定了发病率和病死率。本文对Rb基因在喉癌中的研究进展进行综合综述，以期提供新的治疗手段。

Laryngeal carcinoma is a common head and neck malignant tumor. Multiple genes（e. g, Rb, C-MYC, MDM2, PTEN and other laryngeal carcinoma related genes） and multiple pathways have participated in its occurrence and development. The Rb gene is found the first tumor suppressor gene in humans and mainly plays a suppressor role through regulating the cell cycle. With the further study of Rb gene, we find that Rb gene is closely related to the invasion and metastasis of laryngeal carcinoma, and local recurrence or metastasis of laryngeal carcinoma determines the human morbidity and mortality. According to elaborating the relevance of Rb, C-MYC, MDM2 and PTEN in laryngeal cancer from this paper, we may represent a novel potential therapeutic strategy for clinical intervention.