破骨细胞大小的调控及其机制

Osteoclast size regulation and its mechanism

破骨细胞是一类由骨髓造血干细胞来源的单核/巨噬前体细胞融合分化而来的多核巨细胞,含有大量的抗酒石酸酸性磷酸酶和组织蛋白酶K,具有吸收骨、牙本质等矿化组织的能力.破骨细胞的骨吸收能力与多种疾病的发生、发展密切相关,如牙周炎、根尖周炎、种植体周围炎、骨质疏松症等.破骨细胞大小是衡量破骨细胞骨吸收能力的重要指标.破骨细胞大小的调控及其机制研究,为治疗骨吸收紊乱相关疾病提供了一个新的突破点.本文就国内外相关实验结果,对破骨细胞体积大小的调控及其机制进行综述.

Osteoclasts are multinucleated cells deriving from the monocyte/macrophage haematopoietic lineage.They contain large amount of tartrate resistant acid phosphatase and cathepsin K and play an important role in resorption of mineralized tissues such as bone and dentine.The resorption capabilities by osteoclasts are thought to be associated with several oral diseases such as periodontitis, periapical periodontitis, peri-implantitis and osteoporosis.Osteoclast size is one of the key evaluating parameters of osteoclast resorption activities.Findings of osteoclast size regulation research may provide a novel breakthrough for the treatment of bone resorption disorder diseases.This article summarized and reviewed the previous relevant experiments and studies of osteoclast size regulation and its mechanism.