骨微量元素掺杂对磷酸钙骨水泥水化性能的影响

Effect of Trace Element Doping on the Hydration Properties of Calcium Phosphate Bone Cement

在磷酸钙骨水泥中分别掺杂骨微量元素镁(Mg)、铁(Fe)、锌(Zn)、锶(Sr),考察掺杂离子种类、含量对骨水泥固化时间、羟基磷灰石(HAp)结构、晶形以及骨水泥的抗压强度和孔隙率的影响。结果表明:掺杂不同离子将使骨水泥的固化时间有不同程度的延长;同时,影响水化产物羟基磷灰石的晶体形态。Mg2+掺杂使水化产物HAp晶粒细化,呈板状形态;Sr2+掺杂可获得纳米级晶须,且晶须相互缠绕,二者均有利于材料力学性能的提高。而掺杂Fe3+和Zn2+的骨水泥,其孔隙率明显提高,有利于体液循环和提高材料的生物降解性能。

Bone trace elements, magnesium, iron, zinc and strontium, were incorporated into calcium phosphate bone cement (CPC), and the effects of the species and content of doped ions on the setting time, compression strength and porosity of bone cements, as well as the structure and the morphology of the hydroxyapatite were studied. The results show that doping of trace elements will extend the setting time and influence the morphology of the hydrated product HAp. Magnesium doped CPC is mainly composed of refined platelike particles, and the cement containing strontium becomes a heterogeneous structure with interconnected nano-hydroxyapatite whiskers, which will be benefit to improve the mechanical properties of materials. While the samples doped with iron and zinc exhibit a cavernous network structure with a significantly increased porosity which can promote the circulation of simulated body fluid (SBF) in the doped CPC and improve biodegradability of the as-prepared bone cements.