代谢综合征大鼠模型的建立与评价

Establishment and evaluation of rats model of metabolic syndrome

目的:高盐高脂饲料配合自由饮用果糖水建立代谢综合征大鼠模型。方法:SD大鼠喂饲高盐高脂饲料及自由饮用30%的的果糖水,连续8周。观察大鼠体重等一般状况;检测空腹血糖(FPG)、血脂,称量内脏脂肪重量并计算肥胖指数(Lee,s指数),检测空腹胰岛素(FINS)并计算胰岛素敏感性(ISI)和胰岛素抵抗指数(IRI)。结果:模型组大鼠体重明显增加。Lee,s指数、内脏脂肪重量、内脏脂肪重量/体重明显升高,血清FBG、TG、LDL、FINS含量升高,IRI升高,ISI降低。结论:高盐高脂饲料及饮用高糖饮料8周,可成功建立模型。

Objective： To establish rats model of metabolic syndrome with high salt and high fat feed and fruc- tose water. Methods ：SD rats were fed with high salt and high fat feed and drinking 30 M fructose water for 8 wk consec- utively. To observe the general conditions and body weight of rats; detect fasting blood glucose （FPG）, blood fat;weigh visceral fat weight and calculate obesity index （Lee＇s index）, fasting insulin （FINS） and calculate insulin sensitivity （ISI） and insulin resistance index （IRI）. Results： The weight of rats in the model group increased obviously. Lee^s index, vis- ceral fat weight, visceral fat weight/body weight increased significantly, serum FBG, TG, LDL, FINS content increased, IRI increased, ISI decreased. Conclusion ：The high salt and high fat diet and drinking high sugar beverages for 8 wk can establish rats model of metabolic syndrome successfully.