补肾养血法治疗卵巢早衰的临床效果分析

Clinical analysis of kidney nourishing therapy for premature ovarian failure

目的探讨中医药治疗卵巢早衰的临床疗效,寻求治疗该病的新方法。方法选择2010年9月—2014年9月收治的卵巢早衰患者32例作为研究对象,给予补肾养血汤治疗,1剂/d,早晚分服,3个月为1个疗程。观察患者临床疗效并比较治疗前后患者E2、FSH、LH水平变化情况。计量资料采用配对t检验,P<0.05为差异有统计学意义。结果治疗后,患者血清E2水平为(128.00±31.40)pmol/L,明显高于治疗前的(48.60±19.10)pmol/L,FSH、LH水平分别为(48.70±25.70)、(17.90±3.40)U/L,显著低于治疗前的(66.50±18.20)、(46.30±12.80)U/L,差异均有统计学意义(均P<0.05)。补肾养血汤治疗卵巢早衰总有效率为71.88%。结论补肾养血汤治疗卵巢早衰能显著改善患者临床症状及血清FSH、LH、E2水平,从根本上调整患者内分泌功能,提高体内雌激素水平,恢复卵巢功能,无明显不良反应,是治疗卵巢早衰的安全、有效方法。

Objective To investigate the efficacy of traditional Chinese medicine in the treatment of premature ovarian failure and to seek a new treatment for the disease.Methods 32 patients with premature ovarian failure from September 2010 to September 2014 were recruited in our study.They were treated for the method by tonifyingMdney and nourishing blood.The decoction of Chinese medicine was given one agent every day.Every agent was divided into twice and 3 months for 1 courses.The main clinical symptoms and the changes in E2,FSH and LH were observed before and after treatment.The measurement data was processed by paired t test,P〈0.05 was cousidered statistically significant.Results By the end of treatment, the level of E2 was （128.00± 31.40） pmol/L, higher than that before treatment [（48.60± 19.10）pmol/L],the difference was statistically significant（P〈0.05）.The level of FSH and LH were （48.70 ± 25.70）,（17.90 ± 3.40）U/L,lower than that before treatment[（66.50 ±18.20）,（46.30 ± 12.80）U/L], the dif- ferences were statistically significant（all P〈0.05）.The total efficiency of the method of tonifying kidney and nourishing blood was 71.88%.Conclusion The method of tonifying kidney and nourishing blood had significant effect in treatment of POF,which could significantly improve the serum sex hormones levels and clinical symptoms, promote the recovery of ovarian function.It had not adverse reactions to the drug treatment.It was safe and effective in the treatment of premature ovarian failure.