多b值弥散加权成像对老年前列腺增生与前列腺癌的诊断价值

Diagnostic value of multi-b-value diffusion-weighted imaging in elderly prostatic hyperplasia and prostate cancer

目的探讨多b值弥散加权成像(diffusion weighted imaging,DWI)技术用于老年前列腺增生与前列腺癌的诊断价值。方法选择2014年3月—2015年3月收治的经临床病理学确诊的前列腺癌患者16例作为前列腺癌组和前列腺增生患者12例作为前列腺增生组。患者均通过磁共振成像仪行DWI检查,b值分别为0、400、800、1 200 s/mm2。测量并比较两组患者的b值-信号强度曲线并计算信号衰减率以及曲线的斜率,测量标准弥散系数(apparent diffusion coefficient,ADC)。计量资料采用t检验,P<0.05为差异有统计学意义。结果 b值为0、400、800、1 200 s/mm2时,前列腺癌组的信号强度分别为(520.46±157.02)、(460.57±81.49)、(349.41±80.32)、(183.16±75.62);前列腺增生组分别为(605.68±147.03)、(477.10±78.42)、(295.25±68.45)、(145.06±53.46);在相同b值条件下,两组信号强度比较差异均无统计学意义(均P>0.05)。前列腺癌组的ADC值和信号衰减率分别为(5.91±1.42)%、(76.48±11.39)%,显著低于前列腺增生组的(11.10±1.53)%、(88.58±3.71)%,差异均有统计学意义(均P<0.05)。结论 DWI中信号衰减率及ADC值对老年前列腺癌与前列腺增生的无创诊断具有较大帮助。

Objective To investigate the diagnostic value of multi-b-value diffusion weighted imaging（DWI） in elderly prostatic hyperplasia and prostate cancer.Methods 16 cases of prostate cancer and 12 cases of benign prostatic hyperplasia were con- firmed by clinical pathology from March 2014 to March 2015 were selected.Patients were all use magnetic resonance imager ob- tain DWI,b values were 0,400,800,1 200 s/mm2.The b value-signal intensity curves and calculate signal attenuation ratio,slope of the curve,apparent diffusion coefficient（ADC） of the two groups were measured and compared.Measurement data was processed by t test,P〈0.05 was considered statistically significant.Results . When b were 0,400,800,1 200 s/mm2,the signal strength of the prostate cancer group were （520.46 ±157.02）,（460.57 ± 81.49）,（349.41 ± 80.32）,（183.16 ±75.62）,in the prostatic hyperplasia group were （605.68 ± 147.03）,（477.10 ± 78.42）,（295.25 ± 68.45）,（145.06 ± 53.46）.In the same b value condition,the differences between two sets of signal strength were not statistically significant （all P〉0.05）.ACD and signal attenuation rate of the prostate cancer group were （5.91 ± 1.42）%,（76.48 ± 11.39）%,lower than that in the benign prostatic hyperplasia group[（11.10 ±1.53）%,（88：58 ±3.71）%],the differences were statistically significant（all P〈0.05）.Conclusion Slope of the b value-signal curve and ADC in DWI have great help in non-invasive diagnosis of older prostate cancer and prostate hyperplasia.