胸膜孤立性纤维性肿瘤的临床病理特征分析

Immunohistochemistry of solitary fibrous tumor of the pleura

目的探讨胸膜孤立性纤维性肿瘤的临床病理特征。方法选取2011年4月至2014年3月间收治的38例胸膜孤立性纤维性肿瘤患者,收集其临床特征及组织病理学资料,免疫组化检测CD34、波形蛋白(Vimentin)、CD68、CD99、平滑肌肌动蛋白(SMA)、Bcl-2、S100和EMA表达。结果38例胸膜孤立性纤维性肿瘤患者中,CD34、Vimentin、CD99、SMA和Bcl-2均在肿瘤细胞胞质内表达,阳性表达率分别为100.0%、100.0%、65.8%、5.3%和78.9%,CD68、S100、EMA呈阴性。结论胸膜孤立性纤维性肿瘤较少见,组织学形态多样,应注意与其他间叶源性肿瘤相鉴别,可结合其组织学形态及免疫组化染色结果确诊。

Objective To investigate the clinicopathologic feature and immunohistochemistry of solitary fibrous tumor of the pleura. Methods From April 2011 to March 2014 in The First People＇s Hospital of Shaoguan,the clinicopathologic features of 38 cases with solitary fibrous tumor of the pleura were analyzed. CD34,Vimentin,CD68,CD99,smooth muscle actin（ SMA）,B cell lymphoma-2（ Bcl-2）,S100 and EMA were detected by immunohistochemistry. Results In 38 cases with solitary fibrous tumor of the pleura,CD34,Vimentin,CD99,SMA and Bcl-2 were expressed in the cytoplasm of cells,and the positive rates were 100. 0%,100. 0%,65. 8%,5. 3% and 78. 9%,while the expression of CD68,S100,EMA showed negative. Conclusions Solitary fibrous tumor of the pleura was rare tumor,with diverse histopathology,which should be differentiated from other mesenchymal tumors by combined histopathology and immunohistochemistry.