飞秒激光小切口角膜基质透镜取出术在眼科临床应用的新进展

Advance of femtosecond small incision lenticule extraction （SMILE） in clinic application

飞秒激光小切口角膜基质透镜取出术（SMILE）在国内开展已有5年余，随着技术的逐渐发展日臻成熟，临床上也取得了显著的效果，更因其无瓣、微创，屈光稳定性好等特点，得到临床的关注和推广。而取出的角膜基质微透镜组织的再利用，为角膜屈光手术由减法变加法带来可能，成为SMILE技术近来的延伸热点。本综述从SMILE技术在角膜屈光手术方面和组织材料的再利用等发面的临床效果、相关的基础研究及其未来的发展方向进行阐述。

Femtosecond small incision lenticule extraction （SMILE） had been performed in clinic more than 5 years in China. With the gradual development of the technology, SMILE has caused more and more attention because of the remarkable clinical effect, micro incision, minimally invasive and refractive stability. The reuse of the refractive lenticule （RL） from SMILE has recently become extensive focus, which brings potential method to corneal refractive surgery from subtraction to addition. This review has clarified the technology of SMILE on the aspects of corneal refractive correct, the clinical effect of reuse the materials （RL）, the basis of related research and the possible improvement in the future.