绒毛膜促性腺激素注射日直径≥17mm卵泡占比与妊娠结局的关系

The correlation analysis between pregnancy outcome and the ratio of follicles diameter equal or over 17mm on hCG injection day

目的：回顾性分析绒毛膜促性腺激素（hCG）注射日直径≥17mm卵泡占比与妊娠结局的关系。方法：根据hCG注射日直径≥17mm卵泡在直径≥14mm卵泡中的占比分为3组,其中〈50%者为A组;50%～70%为B组;〉70%为C组,比较3组妊娠结局。结果：3组直径≥14mm卵泡的每卵泡数平均雌二醇（E2）水平、获卵率,受精率无统计学差异（P〉0.05）。hCG日A组E_2（18695.93±13289.03pmol/L）、孕酮（5.25±8.43nmol/L）水平均高于B组（13822.65±8747.08pmol/L、3.85±1.75nmol/L）、C组（11909.99±9878.43pmol/L,3.63±1.53nmol/L）,差异有统计学意义（P〈0.05）;A组优质胚胎率（41.03%）、胚胎种植率（28.93%）、临床妊娠率（39.62%）低于B组（43.76%、30.70%、47.9%）、C组（45.40%、35.22%、51.14%）,差异有统计学意义（P〈0.05）。结论：hCG注射日直径≥17mm卵泡在直径≥14mm卵泡中占比达到50%以上,可获得更好的妊娠结局,可作为确定控制性超排卵hCG注射时机的主要指标。

Objective：A retrospectively analysis was conducted to explore the correlation analysis between pregnancy outcome and the ratio of follicles diameter equal or over 17 mm on hCG injection day.Methods：According to the ratio of follicles diameter≥17mm in the follicles diameter ≥14mm,all patients were divided into 3 groups.Group A：the ratio was less than 50%.Group B：the ratio was between 50-70%.Group C：the ratio was more than 70%.Results：There were no significant differences among the three groups on average serum estradiol（E2） of each follicle with diameter ≥14mm,the number of oocytes retrieved and the fertilization rate（P〈0.05）.The serum E_2 of group A,group B and C was 18695.93±13289.03pmol/L,13822.65±8747.08pmol/L or 11909.99±9878.43pmol/L,respectively,E_2 in group A was significantly higher than that of group B and C（P〈0.05）.The serum P of group A,group B and C was5.25±8.43nmol/L,3.85±1.75nmol/L,3.63±1.53nmol/L,P（progesterone） in group A was significantly higher than that of group B and C（P〈0.05）.However,the rate of good embryo,rate of embryo implantation or rate of pregnancy was lower in group A（41.03%,28.93%,39.62%） than that of group B（43.76%、30.70%、47.9%） and group C（45.40%,35.22%,51.14%）,which had significantly differences（P〈0.05）.Conclusion：Women with The ratio of follicles diameter ≥17mm in the follicles diameter ≥14mm more than 50% on hCG injection day will get a better pregnancy outcome,and it can be used as a main indicator for hCG injection.