摘要
胃癌是世界范围内常见肿瘤之一,因胃癌死亡的患者数占据肿瘤相关死因的第3位.肝再生磷酸酶-3(phosphatase of regenerating liver 3,PRL-3)作为一个新近发现的蛋白酪氨酸磷酸酶,近年来研究发现其在胃癌组织中高表达,在胃癌淋巴转移、腹膜转移等发挥重要作用,与胃癌患者预后负相关.其后,越来越多的研究关注其在胃癌发生、发展中的调控机制,以期阐明PRL-3在胃癌发生、发展中的具体调节通路及影响因素.尽管随着研究的不断深入,对于PRL-3在胃癌中的作用机制得到一部分阐释,但对于P R L-3在促进胃癌淋巴转移、腹膜转移等恶性进展及复发的机制仍然不是很清楚,本文即对近年来PRL-3的相关研究进展作一综述.
Gastric carcinoma is one of the most common malignancies worldwide and remains the third leading cause of cancer death in both sexes worldwide. Phosphatase of regenerating liver 3（PRL-3） is a tyrosine phosphatase that has been reported to be overexpressed in gastric tissues and play an important role in lymphatic metastasis and peritoneal metastasis of gastric carcinoma. It has also been reported that PRL-3 has a negative relationship with the prognosis of gastric carcinoma patients. More and more researchers have focused on the regulatory mechanism of PRL-3 in gastric carcinoma, aiming to elucidate the possible pathway and influencing factors. However, the exact mechanism of PRL-3 in promoting lymphatic metastasis, peritoneal metastasis and recurrence of gastric cancer is unknown. This paper will review the role of PRL-3 in gastric carcinoma with regard to its structure, function and possible mechanism in gastric carcinoma development.
出处
《世界华人消化杂志》
CAS
2016年第1期59-66,共8页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
Nos.81160304
81360362
江西省教育厅科学技术研究基金资助项目
No.CJJ13126
江西省青年科学家培养计划基金资助项目
No.20133BCB23028
南昌大学研究生创新专项资金资助项目
No.cx2015189~~
关键词
肝再生磷酸酶-3
胃癌
淋巴转移
腹膜转移
复发
Phosphatase of regenerating liver 3
Gastric carcinoma
Lymphatic metastasis
Peritoneal metastasis
Recurrence
