肝大部切除后肝脏再生的研究进展

Liver regeneration after partial hepatectomy

肝部分切除后肝脏的再生是一个极其复杂的病理生理过程,涉及多种与细胞增殖有关蛋白基因的上调和转录因子的激活.目前,有关启动、维持及终止肝再生分子机制的研究仍较活跃,是再生医学领域的研究热点之一.研究肝细胞的再生机制可为临床上促进肝脏再生、防治肝衰竭奠定理论基础,具有十分重要临床的意义.本文就部分肝切除后肝细胞再生的启动、增殖和终止的分子机制作一综述.

Liver regeneration after partial hepatectomy is an extremely complicated pathophysiologic process, which involves the up-regulation ofmany proliferation associated proteins and genes. The molecular mechanisms responsible for initiating, maintaining, and terminating this process are still under active investigation and remain one of the research focuses in the field of regenerative medicine. Studies of the mechanism of liver regeneration can provide a theoretical foundation for regeneration promotion and hepatic failure prevention,which isextremely important inclinic a l practice. This review aims to elucidate the molecular mechanism responsible for the initiation, proliferation and termination of liver regeneration.