莪术提取物调控支架后再狭窄血管平滑肌细胞增殖的研究进展

Research progress on curcuma zedoary extracts inhibiting vascular smooth muscle cell proliferation in pathological process of in-stent restenosis

血管平滑肌细胞(vascular smooth muscle cells,VSMCs)异常增殖是支架后再狭窄(in-stent restenosis,ISR)的主要病理过程。近年来研究表明,莪术提取物具有抑制VSMCs增殖,进而抑制支架后再狭窄的作用,其发挥作用的有效成分主要有姜黄素和β-榄香烯,其可能的机制与抑制血红素氧合酶-1(hemeoxygenase-1,HO-1)表达、细胞外信号调节激酶(extracellular signal-regulated kinase,ERK)MAPK、Akt信号通路,阻滞细胞周期进程相关。该文就近年来莪术提取物调控支架后再狭窄VSMCs增殖的研究进展作一综述。

Vascular smooth muscle cells( VSMCs) proliferation is the critical pathological process of in-stent restenosis( ISR).Recent researches indicate that the traditional Chinese medicine curcuma zedoary( E'zhu) can inhibit VSMCs proliferation,with a potential value in preventing and treating ISR. The major active components of curcuma zedoary are curcuma and β-elemene.The underlying mechanisms involve the inhibition of hemeoxygen-ase-1 expression,blockade of extracellular signal-regulated kinase – MAPK and Akt pathways,and subsequent cell cycle arrest. This article reviews the recent progress on curcuma zedoary extracts regulating VSMCs proliferation in ISR.