孕中期唐氏筛查对降低缺陷儿出生的临床意义

The Clinical Significance of the Second Trimester down Syndrome Screening in Reducing Birth Defects

目的：探究孕中期唐氏筛查对降低缺陷儿出生的临床意义.方法：选取某院2013年5月-2015年2月诊治的1600例孕妇,对其采用血清AFP和β-HCG的方法进行检测,检测的内容要结合患者的年龄和体重等问题,使用配套软件对可能会出现唐氏综合征的幼儿进行计算.如高危的孕妇,羊水胎儿细胞染色体的情况进行分析.结果：1600例孕妇其中高危唐氏综合征妇女占86例（约5.42%）,21-三体综合征有34例（2.12%）,神经管缺陷的患者占21例（1.32%）.结论：产前需要对孕妇进行唐氏综合征的筛查工作,能够在第一时间发现胎儿的缺陷问题,控制缺陷胎儿的出生概率,临床效果佳,值得推广.

Objective:To explore the clinical significance of the second trimester Down syndrome screening in reducing birth defects.Methods:Select 1600 cases of pregnant women who received treatment in hospital during the period from May 2013 to February 2015,the methods adpoted to use the serum AFP andβ-HCG should be tested and problems such as patient's age and weight should be considered.Matching software should be used to calculate the rate of fetal with Down syndrome.Such as high-risk pregnant women or the situation of the amniotic fluid chromosome.Results:Among the 1600 cases of pregnant women,women with high risk Down syndrome accounted for 86cases(about 5.42%),21 trisomy syndrome accounted for 34cases(2.12%),neural tube defect patients accounted for 21cases(1.32%).Conclusion:Doing Down syndrome screening before giving birth can detect fetal defects in the first time and control birth probability of defective fetal,which has good clinical effect and is worthy to be promoted.