63例硝苯地平控释片联合缬沙坦治疗老年2型糖尿病肾病合并高血压临床效果分析

The Clinical Effect Analysis of 63 Cases of Combined Treatment of Elderly Type 2 Diabetic Nephropathy and Hypertension by Nifedipine Controlled Release Tablet and Valsartan

目的：分析硝苯地平控释片联合缬沙坦治疗老年2型糖尿病肾病（DN）合并高血压的临床效果.方法：选取2013年7月-2015年5月收治的126例糖尿病肾病患者作为观察目标,按照1：1比例分为对照组（n=63,单纯采用硝苯地平控释片治疗）和治疗组（n=63,采用硝苯地平控释片联合缬沙坦治疗）,比较两组血压及肾功能改变情况.结果：两组血SCr、K＋ 水平以及BUN 进行比较,差异无统计学意义（P 〉0.05）;治疗组SBP、DBP及UAER等均显著优于对照组,组间数值比较具有统计学意义（P 〈0.05）.结论：老年2型糖尿病肾病合并高血压患者应用硝苯地平控释片联合缬沙坦联合治疗方案可显著提高治疗效果,具有积极的临床使用和推广意义.

Objective:To study the clinical effect of combined treatment of elderly type 2diabetic nephropathy and hypertension by nifedipine controlled release tablet and valsartan.Methods:Select 126 cases of diabetic nephropathy patients received by a community health service center during the period from July 2013 to May 2015 as subjects.Divide them into two groups by the ratio 1∶1.The treatment group was given nifedipine controlled release tablet combined with valsartan treatment while the control group was given purely nifedipine controlled release tablet treatment.Compare the change of blood pressure and kidney function of patients in the two groups.Results:Compare the blood SCr,K+level and BUN in the two groups,there was no significant difference(P>0.05).The SBP,DBP and UAER in treatment group were significantly better than those in control group,the differences were statistically significant(P <0.05).Conclusion:Combined treatment of elderly type 2diabetic nephropathy and hypertension by nifedipine controlled release tablet and valsartan has positive clinical effect and is worth to be promoted.