宫颈上皮细胞稳定性FH检测与TCT技术在宫颈病变筛查中的应用价值

Clinical diagnostic value of cells free ferrous protoporphyrin and thin-cytologic test for cervical lesions

目的探讨细胞游离亚铁原卟啉(cells free ferrous protoporphyrin,FH)检测和液基薄层细胞学检测(thin-cytologic test,TCT)技术在宫颈病变筛查中的价值。方法选取同时具有TCT检测结果及病理检查结果的宫颈筛查患者100例,对其进行FH检测,以病理检查结果作为诊断金标准(CINⅠ及以上为阳性),分别计算FH、TCT 2种检测方法在宫颈病变筛查中的敏感度、特异度、准确度、阳性预测值、阴性预测值。结果 FH检测筛查的敏感度、特异度、准确度、阳性预测值和阴性预测值分别是82.9%(58/70)、70.0%(21/30)、79.0%(79/100)、86.6%(58/67)和63.6%(21/33),TCT筛查的敏感度、特异度、准确度、阳性预测值和阴性预测值分别是87.1%(61/70)、76.6%(23/30)、84.0%(84/100)、89.7%(61/68)和71.9%(23/32),2种检测方法的检验效能比较差异无统计学意义(P>0.05);2种检测方法联合使用可提高检验效能。结论 FH检测作为宫颈病变筛查的新方法,简便、经济,具有与TCT同样高的临床应用价值。FH检测联合TCT技术用于宫颈病变的筛查,可提高宫颈病变的检出率。

Objective To investigate the clinical value of cells free ferrous protoporphyrin（FH）and thin-cytologic test（TCT）in the screening of cervical lesions.Methods FH was used to examine 100 patients who had both TCT results and pathological examination results.Based on gold standard of pathological examination（〉CIN Ⅰ was defined as positive）,the sensitivity,specificity,accuracy,positive predictive value,negative predictive value of FH test and TCT were calculated,respectively. Results The sensitivity,specificity,accuracy, positive predictive value,negative predictive value of FH were 82.9%（58/70）,70.0%（21/30）,79.0%（79/100）,86.5%（58/67）and 63.6%（21/33）.The sensitivity,specificity,accuracy,positive predictive value,negative predictive value of TCT were 87.1%（61/70）,76.6%（23/30）,84.0%（84/100）,89.7%（61/68）and 71.9%（23/32）.The effectiveness of two methods had no statistical significance（P〉0.05）.The efficiency increased when the two test methods jointed.Conclusion FH test as a new method for cervical lesions screening is simple,economic,and has same clinical value as TCT.The method FH jointing TCT for cervical lesions screening has higher efficiency.