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苯妥英的遗传药理学进展 被引量:5

Development of pharmacogentics on phenytoin
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摘要 目前研究认为基因多态性是抗癫疒间药物苯妥英个体差异的重要原因,基因多态性导致癫疒间患者个体出现不同的苯妥英药理、毒理作用。随着遗传药理学的不断深入研究,研究者对苯妥英用药有了新的认识。本文介绍了苯妥英的遗传药理学研究进展。 Genetic polymorphisms has important meaning for individual differences of antiepileptic drug-phenytoin and play a vital role in pharmacological and toxicological effects on phenytoin.With the development of pharmacogentics,we have a wider view for phenytoin.This paper discusses the advances of pharmacogenetics about phenytoin.
出处 《实用药物与临床》 CAS 2016年第1期105-109,共5页 Practical Pharmacy and Clinical Remedies
关键词 苯妥英 基因多态性 MDR1(ABCB1) CYP2C9 SCN1A SCN2A HLA-B MTHFR Phenytoin Genetic polymorphisms MDR1(ABCB1) CYP2C9 SCN1A SCN2A HLA-B MTHFR
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