期刊文献+

IL-10在神经系统疾病中的研究进展 被引量:2

下载PDF
导出
摘要 白介细胞素-10(Interleukin-10,IL-10)是由160个氨基酸构成的单肽链糖蛋白,相对分子质量为18.7×103。IL-10由活化的星形胶质细胞及小神经胶质细胞产生,它与高亲和性的IL-10受体结合,通过自分泌和旁分泌的方式调节神经胶质介导的炎性反应,于19世纪60年代中叶第一次发现细胞因子的活性,来自体外淋巴细胞上清液中的某种因子能调控细胞增殖,
出处 《现代医药卫生》 2016年第3期389-392,共4页 Journal of Modern Medicine & Health
  • 相关文献

参考文献29

  • 1Buffler M , Becker C , Windisch W, et al. Inflammation neither increases hepatic hepcidin nor affects intestinal (59)Fe-ahsorption in two murine models of bowel inflammation, hemizygous TNF(dAREI+) and homozygous IL-10( -1-) mice[J]. J Trace Elem Med BioI ,2015 ,32: 162-167.
  • 2Garcfa-Rocha R, Moreno-Lafont M, Mora-Garcfa ML, et al. Mesenchymal stromal cells derived from cervical cancer tumors induce TGF -β1 expression and IL-10 expression and secretion in the cervical cancer cells, resulting in protection from cytotoxic T cell activity [J]. Cytokine,2015, 76(2) :382-390.
  • 3Mannino MH, Zhu Z, Xiao H, et al. The paradoxical role ofIL-10 in immunityand cancer[J]. CancerLett, 2015,367 (2) : 103-107.
  • 4Kalampokis I, Yoshizaki A, Tedder TF. IL-10-producing regulatory B cells (BIO cells) in autoimmune disease[J]. Arthritis Res Ther ,2013,15 Suppl 1 :S1.
  • 5Hofmann SR,Riisen-Wolff A,Tsokos GC,et al. Biological properties and regulation of 11-10 related cytokines and their contribution to autoimmune disease and tissue injury[J]. Clin Immunol,2012, 143(2): 116-127.
  • 6Xin J, Wainwright DA,Serpe CJ ,et al. Phenotype of CD4+ T cell subsets that develop following mouse facial nerve axotomy[J]. Brain Behav Immun , 2008,22(4) :528-537.
  • 7Xin J , Wainwright DA , Mesnard NA , et al. IL-I0 within the CNS is necessary for CD4+ T cells to mediate neuroprotection[J]. Brain Behav Immun, 2011 ,25(5) :820-829.
  • 8Villacampa N , Almolda B, Vilella A, et al. Astrocyte-targeted production of IL-10 induces changes in microglial reactivity and reduces motor neuron death after facial nerve axotomy[J]. Glia ,2015,63 (7) : 1166-1184.
  • 9Atkins S, Loescher AR , Boissonade FM , et al. Interleukin-10 reduces scarring and enhances regeneration at a site of sciatic nerve repair[J]. J Peripher Nerv Syst,2007, 12(4) :269-276.
  • 10Koeberle PD, Gauldie J , Ball AK. Effects of adenoviral-mediated gene transfer of interleukin-10, interleukin-4 , and transforming growth factorbeta on the survival ofaxotomized retinal ganglion cells[J]. Neuroscience, 2004,125(4) :903-920.

二级参考文献7

共引文献2

同被引文献13

引证文献2

二级引证文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部