宫颈癌中EGFR和FSCN1的表达及其相关性

Expression and correlation of EGFR and FSCN1 in cervical cancer

目的:探讨宫颈癌中表皮生长因子受体1(EGFR)及Fascin-1(FSCN1)蛋白的表达及其相关性。方法:采用免疫组织化学En Vision法检测120例宫颈癌组织中EGFR及FSCN1蛋白的表达。结果:宫颈癌组织中EGFR蛋白阳性率为89.2%(107/120),FSCN1蛋白阳性率为99.2%(119/120),其中强阳性率为88.3%(106/120)。EGFR阳性表达与FSCN1强阳性表达呈显著正相关(P<0.01)。结论:宫颈癌中EGFR可能参与正性调控FSCN1表达。

Objective： To explore the expression of EGFR and FSCN1 protein in cervical cancer and its correlation. Methods： The expression of EGFR and FSCN1 in 120 cases of cervical cancer was evaluated with immunohistochemical technique, EnVision method. Results： EGFR protein expression rates in cervical cancer was 89.2% （107/120）. FSCN1 protein positive rate in cervical cancer was 99.2% （119/120）, in which strong positive rate was 88.3% （106/120）. EGFR positive expression was significantly positive correlation with FSCN1 strong positive expression （P〈0.01）. Conelusion： EGFR may participate in positive regulation FSCNI expres- sion in cervical cancer.